Leukocyte Common Antigens

High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.

Also Known As:

CD45 Antigen; 2H4 Antigens; B220 Antigen; B220 Antigens; CD45R0 Antigens; CD45RB Antigens; CD45RCAntigens; L-CA Antigens; Leukocyte Common Antigen; T200 Antigens; Antigen, B220; Antigen, CD45; Antigen, Leukocyte Common; Antigens, 2H4; Antigens, B220; Antigens, CD45R; Antigens, CD45R0; Antigens, CD45RA; Antigens, CD45RB; Antigens, CD45RO; Antigens, L-CA; Antigens, Leukocyte Common; Antigens, T200; L CA Antigens; Antigens, CD45; CD45 Antigens; CD45R Antigens; CD45RA Antigens; CD45RO Antigens; Protein Tyrosine Phosphatase, Receptor Type, C

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Protein Tyrosine Phosphatases: 1685
        Receptor-Like Protein Tyrosine Phosphatases: 2
        Class 1 Receptor-Like Protein Tyrosine Phosphatases
        Leukocyte Common Antigens: 366
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Receptor-Like Protein Tyrosine Phosphatases: 2
      - Class 1 Receptor-Like Protein Tyrosine Phosphatases
        Leukocyte Common Antigens: 366
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Tyrosine Phosphatases: 1685
      - Receptor-Like Protein Tyrosine Phosphatases: 2
        Class 1 Receptor-Like Protein Tyrosine Phosphatases
        Leukocyte Common Antigens: 366

human PTPRC protein

Bio-Agent Context: Research Results