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NSC73306

structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - NSC73306: 3

Experts

1.	Ambudkar, Suresh V: 2 articles (12/2007 - 05/2006)
2.	Gottesman, Michael M: 2 articles (12/2007 - 05/2006)
3.	Georges, Elias: 1 article (11/2022)
4.	Limniatis, Georgia: 1 article (11/2022)
5.	Calcagno, Anna Maria: 1 article (12/2007)
6.	Hall, Matthew D: 1 article (12/2007)
7.	Shukla, Suneet: 1 article (12/2007)
8.	Wu, Chung-Pu: 1 article (12/2007)
9.	Caplen, Natasha J: 1 article (05/2006)
10.	Cardarelli, Carol: 1 article (05/2006)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2006 - "Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer." 12/01/2007 - "Collectively, these data suggest that NSC73306 can potentially be used, due to its dual mode of action, as an effective agent to overcome drug resistance by eliminating P-glycoprotein-overexpressing cells and by acting as a potent modulator that resensitizes ABCG2-expressing cancer cells to chemotherapeutics." 11/01/2022 - "All three P-glycoprotein-knockout clones of CHORC5 cells show complete loss of resistance to anti-cancer drugs (e.g., colchicine and doxorubicin), while gaining resistance to well characterized collateral sensitivity drugs (e.g., verapamil, progesterone and NSC73306). "
2.	Hypersensitivity (Allergy) 05/01/2006 - "Although hypersensitivity to NSC73306 required functional expression of P-gp, biochemical assays revealed no direct interaction between NSC73306 and P-gp. "
3.	Colonic Neoplasms (Colon Cancer) 05/01/2006 - "Cytotoxic activity of NSC73306 was evaluated in vitro using human epidermoid, ovarian, and colon cancer cell lines expressing various levels of P-gp. "
4.	Carcinoma (Carcinomatosis) 12/01/2007 - "We previously reported that a thiosemicarbazone derivative, NSC73306, is cytotoxic to carcinoma cells that overexpress functional P-glycoprotein, and it resensitizes these cells to chemotherapeutics. "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Verapamil (Calan)
3.	Thiosemicarbazones
4.	Progesterone
5.	Doxorubicin (Adriamycin)
6.	Colchicine