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mensacarcin
structure in first source
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
mensacarcin: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Anthracenes: 12
mensacarcin: 2
Experts
1.
Loesgen, Sandra
: 2 articles (05/2018 - 12/2017)
2.
Plitzko, Birte
: 2 articles (05/2018 - 12/2017)
3.
Kaweesa, Elizabeth N
: 1 article (12/2017)
Related Diseases
1.
Neoplasms (Cancer)
05/20/2018 - "
With this protocol, we sought to assess basal mitochondrial function and mitochondrial stress of three different cancer cell lines in response to the cytotoxic test lead compound mensacarcin in order to investigate its mechanism of action.
"
2.
Melanoma (Melanoma, Malignant)
12/22/2017 - "
Mensacarcin's unique mode of action suggests that it may be a useful probe for examining energy metabolism, particularly in BRAF-mutant melanoma, and represent a promising lead for the development of new anticancer drugs.
"
12/22/2017 - "
The subcellular localization of the fluorescently labeled mensacarcin together with its unusual metabolic effects in melanoma cells provide evidence that mensacarcin targets mitochondria.
"
12/22/2017 - "
Flow cytometry identified a large population of apoptotic melanoma cells, and single-cell electrophoresis indicated that mensacarcin causes genetic instability, a hallmark of early apoptosis.
"
12/22/2017 - "
The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells.
"
12/22/2017 - "
Upon mensacarcin exposure, SK-Mel-28 and SK-Mel-5 melanoma cells, which have the BRAFV600E mutation associated with drug resistance, showed characteristic chromatin condensation as well as distinct poly(ADP-ribose)polymerase-1 cleavage.
"
Related Drugs and Biologics
1.
Cytostatic Agents
2.
Caspase 3 (Caspase-3)
3.
Chromatin
Related Therapies and Procedures
1.
Therapeutics