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crinane

structure in first source

Networked: 9 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Amaryllidaceae Alkaloids: 33
        crinane: 9
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Amaryllidaceae Alkaloids: 33
    - crinane: 9

Experts

1.	Havelek, Radim: 2 articles (04/2019 - 03/2014)
2.	Nair, Jerald J: 2 articles (04/2019 - 04/2014)
3.	van Staden, Johannes: 2 articles (04/2019 - 04/2014)
4.	Cahlíková, Lucie: 1 article (04/2019)
5.	De Simone, Angela: 1 article (04/2019)
6.	Hrabinova, Martina: 1 article (04/2019)
7.	Hulcová, Daniela: 1 article (04/2019)
8.	Kohelová, Eliška: 1 article (04/2019)
9.	Korábečný, Jan: 1 article (04/2019)
10.	Kučera, Tomáš: 1 article (04/2019)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2014 - "The crinane group of the Amaryllidaceae, including haemanthamine and haemanthidine, was amongst the first of these compounds to exhibit an interesting cytotoxic potential against cancer cell lines. " 01/01/2022 - "The purpose of the current study was to determine if the isocarbostyrils narciclasine, pancratistatin, lycorane, lycorine, crinane, and haemanthamine inhibit phenomena related to cancer progression in vitro. " 01/01/2018 - "Following the success of these natural products, in this review, twenty-six types of isoquinoline alkaloids (a total of 379 alkaloids), including benzyltetrahydroisoquinoline, aporphine, oxoaporphine, isooxoaporphine, dimeric aporphine, bisbenzylisoquinoline, tetrahydroprotoberberine, protoberberine, protopine, dihydrobenzophenanthridine, benzophenanthridine, benzophenanthridine dimer, ipecac, simple isoquinoline, pavine, montanine, erythrina, chelidonine, tropoloisoquinoline, azafluoranthene, phthalideisoquinoline, naphthylisoquinoline, lycorine, crinane, narciclasine, and phenanthridone, were summarized based on their cytotoxic and MDR reversing activities against various cancer cells. "
2.	Adenocarcinoma 04/01/2014 - "Crinane alkaloids of the amaryllidaceae with cytotoxic effects in human cervical adenocarcinoma (HeLa) cells." 04/01/2014 - "In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 microM)."
3.	Malaria 04/01/2019 - "This review focuses on the in vitro activities demonstrated by its crinane alkaloids against various strains of the malaria-causing parasite Plasmodium falciparum. " 03/21/2023 - "In this work, the activity of twenty-eight Amaryllidaceae alkaloids (1-28) belonging to seven different structural types was assessed, as well as twenty semisynthetic derivatives of the β-crinane alkaloid ambelline (28a-28t) and eleven derivatives of the α-crinane alkaloid haemanthamine (29a-29k) against the hepatic stage of Plasmodium infection. "
4.	Lung Neoplasms (Lung Cancer) 10/01/2018 - "All isolates were in vitro evaluated for their cytotoxic activity against seven lung cancer cell lines, in addition to antimicrobial activity for eight bacteria, scavenging potential using ABTS·+ and DPPH test, and anti-inflammatory activity for Cox-1 and Cox-2 which had not previously been tested for crinane-type alkaloids with the cleavage between C-1 and C-13. "
5.	Hypoxia (Hypoxemia) 10/01/2006 - "In a search for natural product inhibitors of hypoxia inducible factor-1 (HIF-1) function, crinamine (1), a crinane type alkaloid, showed potent dose dependent inhibition (IC50 = 2.7 microM) of HIF-1alpha in a cell-based reporter gene assay. "

Related Drugs and Biologics

1.	hemanthamine
2.	hemanthidine
3.	Alkaloids
4.	lycorine
5.	narciclasine
6.	distichamine
7.	lycorane
8.	pancratistatin
9.	Amaryllidaceae Alkaloids
10.	Benzylisoquinolines