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azadirone

from Azadirachta indica A. Juss; structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Limonins: 143
        azadirone: 2

Experts

1.	Aggarwal, Bharat B: 1 article (11/2013)
2.	Francis, Sajin K: 1 article (11/2013)
3.	Gupta, Subash C: 1 article (11/2013)
4.	Mo, Yin-Yuan: 1 article (11/2013)
5.	Nair, Mangalam S: 1 article (11/2013)
6.	Deevi, Dhanvanthri S: 1 article (11/2003)
7.	Kasu, Sridevi: 1 article (11/2003)
8.	Kumar, P Mahesh: 1 article (11/2003)
9.	Kumar, R Ajaya: 1 article (11/2003)
10.	Nanduri, Srinivas: 1 article (11/2003)

Related Diseases

1.

Neoplasms (Cancer)

11/17/2003 - "Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. "
11/08/2013 - "These effects of azadirone were cancer cell-specific. "
11/08/2013 - "Results indicate that azadirone sensitized cancer cells to TRAIL. "
11/08/2013 - "Overall, this study indicates that azadirone can sensitize cancer cells to TRAIL through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. "
11/08/2013 - "We investigated whether azadirone, a limonoidal tetranortriterpene, can sensitize human tumor cells to TRAIL. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Death Domain Receptors
3.	Limonins
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Ligands