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neoamphimedine

a Pyrido[4,3,2-mn]acridine from Indo-Pacific sponge genus Xestospongia; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 327
      - neoamphimedine: 3

Experts

1.	Amagata, Taro: 1 article (01/2012)
2.	Crews, Phillip: 1 article (01/2012)
3.	Edelstein, Matthew: 1 article (01/2012)
4.	Johnson, Tyler A: 1 article (01/2012)
5.	Media, Joseph: 1 article (01/2012)
6.	Pietraszkiewicz, Halina: 1 article (01/2012)
7.	Tenney, Karen: 1 article (01/2012)
8.	Valeriote, Frederick A: 1 article (01/2012)
9.	Abraham, Adedoyin D: 1 article (01/2011)
10.	Amerin, Courtney L: 1 article (01/2011)

Related Diseases

1.

Neoplasms (Cancer)

08/01/2003 - "Neoamphimedine also showed potent anti-neoplastic activity in human xenograft tumors in athymic mice. "
01/01/2011 - "These findings support the continued development of neoamphimedine as an anticancer agent, particularly in solid tumors that over-express Metnase."
08/01/2003 - "Neoamphimedine was as effective as etoposide in mice bearing KB tumors and as effective as 9-aminocamptothecin in mice bearing HCT-116 tumors. "
01/01/2012 - "Solid tumor selective compounds included fascaplysin and 10-bromofascaplysin (Fascaplysinopsis), neoamphimedine, 5-methoxyneoamphimedine and alpkinidine (Xestospongia), makaluvamine C and makaluvamine H (Zyzzya), psymberin (Psammocinia and Ircinia), and ethylplakortide Z and ethyldidehydroplakortide Z (Plakortis). "

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Antineoplastic Agents (Antineoplastics)
3.	psymberin
4.	makaluvamine H
5.	9-aminocamptothecin
6.	fascaplysine