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stemofoline

RN given for (2S-(2alpha,3beta,4beta,5alpha,5abeta,6beta,8abeta,9S*))-isomer; structure in first source

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - stemofoline: 3

Experts

1.	Pyne, Stephen G: 2 articles (12/2018 - 01/2013)
2.	Umsumarng, Sonthaya: 2 articles (12/2018 - 01/2013)
3.	Limtrakul, Pornngarm: 2 articles (01/2013 - 12/2011)
4.	Limtrakul Dejkriengkraikul, Pornngarm: 1 article (12/2018)
5.	Mapoung, Sariya: 1 article (12/2018)
6.	Yodkeeree, Supachai: 1 article (12/2018)
7.	Jatisatienr, Araya: 1 article (01/2013)
8.	Pintha, Komsak: 1 article (01/2013)
9.	Pitchakarn, Pornsiri: 1 article (01/2013)
10.	Sastraruji, Kwankamol: 1 article (01/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "These results indicate that stemofoline derivatives reversed P-gp-mediated multidrug resistance in vitro, and thus could be developed as effective chemosensitizers to treat multidrug-resistant cancers. " 12/01/2011 - "Taken together, the results exhibit that stemofoline possesses an effective MDR modulator, and may be used in combination with conventional chemotherapeutic drugs to reverse MDR in cancer cells." 12/25/2018 - "Our previous study reported that stemofoline (STF) exhibited a synergistic effect with chemotherapeutic drugs in human multidrug-resistant (MDR) leukemic cells (K526/Adr) by inhibiting the function of P-glycoprotein, which is a membrane transporter that is overexpressed in several types of MDR cancers. " 01/01/2013 - "We found that three out of the twelve stemofoline derivatives including OH-A1, NH-B6 and NH-D6 showed commitment efficiency to increase sensitivity to doxorubicin, vinblastine and paclitaxel in KB-V1 cells and increase sensitivity to doxorubicin, and paclitaxel in K562/Adr cells whereas the effects have not been seen in their parental sensitive cancer cell lines (KB-3-1 and K562). "
2.	Carcinoma (Carcinomatosis) 12/01/2011 - "In the present study, we have focused on the effect of stemofoline on the modulation of P-gp function in a multidrug resistant human cervical carcinoma cell line (KB-V1). " 01/01/2013 - "We examined the multidrug resistance reversing property of stemofoline derivatives in drug-resistance human cervical carcinoma (KB-V1) and human leukemic (K562/Adr) cell lines that overexpress P-gp. "

Related Drugs and Biologics

1.	Membrane Transport Proteins (Biological Pump)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Paclitaxel (Taxol)
4.	Vinblastine (Vinblastine Sulfate)
5.	Doxorubicin (Adriamycin)