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hemoglobin S-Oman

beta6 Glu replaced by Val and beta121 Glu replaced by Lys resulting in a dominant sickle syndrome

Also Known As:

Hb S-Oman; HbS-Oman

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Hemoglobins: 38348
      - Abnormal Hemoglobins: 120
        hemoglobin S-Oman: 4
  - Hemeproteins: 196
    - Globins: 2778
      - Hemoglobins: 38348
        Abnormal Hemoglobins: 120
        hemoglobin S-Oman: 4

Experts

1.	Wali, Yasser: 2 articles (01/2022 - 10/2017)
2.	Al-Mashaikhi, Nawal: 1 article (01/2022)
3.	Al-Rawas, Abdulhakim: 1 article (01/2022)
4.	Khater, Doaa: 1 article (01/2022)
5.	Soliman, Ashraf: 1 article (01/2022)
6.	Al Awadi, Maha: 1 article (10/2017)
7.	Al Balushi, Halima W M: 1 article (10/2017)
8.	Al-Subhi, Taimoora: 1 article (10/2017)
9.	Brewin, John N: 1 article (10/2017)
10.	Gibson, John S: 1 article (10/2017)

Related Diseases

1.	Thalassemia 12/01/1998 - "We have studied a pedigree of heterozygous carriers of HbS-Oman that segregates into two types of patients: those expressing about 20% HbS-Oman and concomitant -/ thalassemia and those with about 14% of HbS-Oman and concomitant -/- thalassemia. " 10/01/2002 - "The splenic function was studied in 72 Omani patients with sickle cell disease (50 homozygous for hemoglobin S (HbS-S), 11 double heterozygotes for HbS and beta(0)-thalassemia (HbS-beta(0)-thal), 5 HbS-beta(+)-thal, 5 patients with hemoglobin S-D disease, and 1 child with hemoglobin S oman trait) aged 4.8-16 years, using (99m)Tc-labeled tin colloid scintigraphy. "
2.	Hypersplenism (Anemia, Splenic) 01/01/2022 - "Compound heterozygotes HbS-Oman resulted in very severe clinical manifestations with transfusion-dependency and hypersplenism early in life. "
3.	Hemoglobinopathies 01/01/2022 - "The unique existence of HbS-Oman (a severe variant of sickle hemoglobinopathy) markedly increased the severity of the disease. "
4.	Dehydration (Water Stress) 10/01/2017 - "The super sickling behaviour of HbS-Oman may obviate the need for solute loss and red cell dehydration to encourage Hb polymerisation, required in other SCD genotypes. "
5.	Sickle Cell Anemia (Hemoglobin S Disease) 10/01/2002 - "The splenic function was studied in 72 Omani patients with sickle cell disease (50 homozygous for hemoglobin S (HbS-S), 11 double heterozygotes for HbS and beta(0)-thalassemia (HbS-beta(0)-thal), 5 HbS-beta(+)-thal, 5 patients with hemoglobin S-D disease, and 1 child with hemoglobin S oman trait) aged 4.8-16 years, using (99m)Tc-labeled tin colloid scintigraphy. "

Related Drugs and Biologics

1.	Tin
2.	Sickle Hemoglobin
3.	Colloids (Colloid)