punicalagin

12/01/2022 - "In conclusion, punicalagin exerts a strong protective effect on the pancreas against oxidative injury and inflammation in STZ-induced experimental T1DM. "
12/01/2022 - "Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress."
01/01/2022 - "BV2 cells were pre-treated with punicalagin following LPS treatment to induce inflammation. "
01/01/2021 - "Our findings suggested that punicalagin might be one of natural therapeutic compounds for relieving RA progress via suppressing FLSs inflammation and migration through modulating NF-κB pathways."
01/01/2021 - "To investigate the effects of punicalagin on synovial inflammation and bone destruction in RA. "

09/01/2015 - "Although punicalagin has been shown to have various pharmacological effects, such as anti-oxidative, anti-inflammatory, and anti-tumor effects, no studies have reported the effects of punicalagin on osteoclasts (OCLs). "
05/01/2022 - "Punicalagin, which is derived from pomegranate peel, is reported to exert growth-inhibitory effects against various cancers. "
08/09/2021 - "Punicalagin in Cancer Prevention-Via Signaling Pathways Targeting."
06/01/2021 - "Altogether, the punicalagin is a promising phytomedicine in malignancy treatment and further endeavors are needed to unveil the complete potential."
06/01/2021 - "Punicalagin has been documented as a potential phytomedicine to selectively inhibit the progression and expansion of numerous cancers. "

04/03/2023 - "Our previous study revealed that punicalagin (PUN) regulated TET2 in obese mice; however, whether PUN can prevent obesity-induced skeletal muscle dysfunction by regulating TET2 remains unclear. "
04/01/2023 - "Punicalagin(PU), a polyphenol derived from pomegranate peel, is a potential anti-obesity substance. "
11/01/2019 - "Punicalagin, a Pomegranate-Derived Ellagitannin, Suppresses Obesity and Obesity-Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway."
10/10/2014 - "Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin."
09/15/2015 - "In this study, the activation of the AMP-activated protein kinase (AMPK) pathway by punicalagin (PU), a major ellagitannin in pomegranate was investigated in the heart of a rat obesity model. "

05/01/2022 - "It will enable the future applications of punicalagin as a therapeutic for HPV-induced cervical cancer."
05/01/2022 - "The results of in vivo studies demonstrated that punicalagin efficiently inhibits cervical cancer growth. "
04/01/2020 - "Our findings demonstrated that punicalagin repressed the viability of cervical cancer cells in a dosereliant mode via stimulating mitochondrial mediated apoptosis. "
04/01/2020 - "Moreover, our this study demonstrated that punicalagin blocked cervical cancer cell proliferation and stimulated cell apoptosis by suppressing NF-kappa B activity. "
05/01/2022 - "Here, punicalagin markedly downregulated the levels of the major HPV oncoproteins E6 and E7 in cervical cancer cells through the autophagy-lysosome system. "

01/01/2020 - "In the present study, the inhibitory effect of punicalagin on proliferation and invasion was evaluated in one human osteoblast cell line (hFOB1.19) and three human osteosarcoma cell lines (U2OS, MG63 and SaOS2). "
09/01/2020 - "In addition, punicalagin could significantly impede the mobility, migration and invasion abilities of osteosarcoma cells. "
09/01/2020 - "We found that punicalagin inhibited the viability of osteosarcoma cells in vitro in dose-dependent and time-dependent manners and promoted apoptosis. "
09/01/2020 - "Osteosarcoma cell lines (HOS cells, U2OS cells and MG63 cells) were treated with different doses of punicalagin, and the effects on osteosarcoma cell activity were examined in vitro using cell counting kit-8 (CCK-8), colony formation and apoptosis assays. "
01/01/2020 - "Punicalagin treatment significantly decreased osteosarcoma cell proliferation and increased apoptosis. "