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26-deoxyactein

cyclolanostane from the Chinese drug Shoma; structure in first source

Also Known As:

26-deoxy-actein; 27-deoxyactein

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - 26-deoxyactein: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 26-deoxyactein: 1

Experts

1.	Chen, Yajuan: 1 article (07/2016)
2.	Hu, Xiaodong: 1 article (07/2016)
3.	Qing, Chen: 1 article (07/2016)
4.	Qiu, Minghua: 1 article (07/2016)
5.	Wu, Desong: 1 article (07/2016)
6.	Yao, Qi: 1 article (07/2016)

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 07/30/2016 - "Actein and 26-deoxyactein inhibited the proliferation of the 12 human cancer cell lines tested with the values of 50% inhibitory concentrations (IC50) between 12.29 and 88.39 μg/mL. In vivo, both actein (3-27 mg/kg) and 26-deoxyactein (3-27 mg/kg) significantly inhibited the growth of the implanted sarcoma S180 in a dose-dependent manner. "
2.	Neoplasms (Cancer) 07/30/2016 - "Compared with the vehicle control, actein (10, 30 mg/kg) and 26-deoxyactein (10, 30 mg/kg) significantly reduced the MVD in the xenograft tumor. " 07/30/2016 - "Actein and 26-deoxyactein inhibited the proliferation of the 12 human cancer cell lines tested with the values of 50% inhibitory concentrations (IC50) between 12.29 and 88.39 μg/mL. In vivo, both actein (3-27 mg/kg) and 26-deoxyactein (3-27 mg/kg) significantly inhibited the growth of the implanted sarcoma S180 in a dose-dependent manner. "
3.	Leukemia 07/30/2016 - "The FCM result showed that human leukemia HL-60 cells were arrested at G₁ phase after treated with either actein (6.25-25 μg/mL) or 26-deoxyactein (6.25-25 μg/mL) for 48 h. "

Related Drugs and Biologics

1.	actein