spongistatin 1

a highly cytotoxic macrocyclic lactone polyether from a Spongia species; structure given in first source

Also Known As:

altohyrtin A; 8,12,45,46,47,48,50-Heptaoxaheptacyclo(39.3.1.11,5.19,13.115,19.125,29.129,33)pentacont-23-ene-7,35-dione, 3,37-bis(acetyloxy)-11-(7-chloro-4-hydroxy-2-methylene-5,7-octadienyl)-10,14,15,17,27,43-hexahydroxy-31-methoxy-18,36,38,43,49-pentamethyl-39-methyl

Networked: 9 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bach, Jordi: 3 articles (07/2005 - 11/2001)
2.	Coster, Mark J: 3 articles (07/2005 - 11/2001)
3.	Paterson, Ian: 3 articles (07/2005 - 11/2001)
4.	Chen, David Y-K: 2 articles (07/2005 - 11/2001)
5.	Wallace, Debra J: 2 articles (07/2005 - 11/2001)
6.	Aceña, Jose L: 2 articles (02/2003 - 11/2001)
7.	Leighton, James L: 1 article (04/2013)
8.	Reznik, Samuel K: 1 article (04/2013)
9.	Atasoylu, Onur: 1 article (09/2011)
10.	Huang, Kuan-Chun: 1 article (09/2011)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "Our data show that spongistatin 1 represents a promising novel therapeutic agent for the treatment of leukemic tumor cells especially in the clinically highly relevant situation of chemoresistance due to overexpression of XIAP." 04/01/2013 - "Toward a more step-economical and scalable synthesis of spongistatin 1 to facilitate cancer drug development efforts." 09/01/2011 - "The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human fibroblasts. " 09/01/2010 - "Spongistatin 1 significantly reduced tumor growth, which correlates with a strong apoptosis induction (DNA-fragmentation) and long-term effects on clonogenic survival of pancreatic tumor cells (L3.6pl) in vitro. " 09/01/2008 - "In apoptosis-resistant leukemic tumor cells overexpressing XIAP, spongistatin 1 effectively causes cell death and potentiates cell death induction by other apoptosis-promoting factors that might be caused by spongistatin 1-mediated degradation of XIAP. "
2.	Dehydration (Water Stress) 07/07/2005 - "Two structural analogues were also prepared and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, alongside altohyrtin A and paclitaxel (Taxol), revealing that dehydration in the E-ring is tolerated and results in enhanced cytotoxicity (at the low picomolar level), whereas the presence of the full C44-C51 side-chain appears to be crucial for biological activity." 02/21/2003 - "Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring dehydration leads to enhanced cytotoxicity at the low picomolar level while truncation of the side-chain at C46 results in a drastic decrease in activity."
3.	Prostatic Neoplasms (Prostate Cancer) 09/01/2011 - "Consistent with a microtubule-targeting mechanism of action, (+)-spongistatin 1 causes mitotic arrest in DU145 human prostate cancer cells. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 09/01/2010 - "Spongistatin 1 was applied in an orthotopic in vivo model of human pancreatic cancer. "
5.	Neoplasm Metastasis (Metastasis) 09/01/2010 - "The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis." 09/01/2010 - "Taken together, spongistatin 1 not only proved to be a potent experimental drug but also served as a chemical tool to examine the role of the antiapoptotic protein Bcl-2 in pancreas carcinoma, thereby supporting the hypothesis of a link between apoptosis signaling and metastasis."

Related Drugs and Biologics

1.	spongistatin 1
2.	Antimitotic Agents
3.	Macrolides
4.	Paclitaxel (Taxol)
5.	Proteins (Proteins, Gene)
6.	Lactones
7.	Amphotericin B (Amphotericin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)

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