aci-reductone oxidase (CO-forming)

from Klebsiella pneumoniae; involved in conversion of 5'-methylthioadenosine to methionine; converts CH3-S-CH2-CH2-CO-C(OH)=CH-O(-) to carbon monoxide + formate + methylthiopropionic acid; synthesized as two enzymes, E-2 and E-2' which bind nickel or cobalt (E-2) or iron (E-2'); amino acid sequence has been determined; GenBank AF102514

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Albertí-Valls, Manel: 1 article (06/2022)
2.	Bonifaci, Nuria: 1 article (06/2022)
3.	Eritja, Núria: 1 article (06/2022)
4.	Gatius, Sònia: 1 article (06/2022)
5.	Jove, Mariona: 1 article (06/2022)
6.	Llobet-Navas, David: 1 article (06/2022)
7.	Matías-Guiu, Xavier: 1 article (06/2022)
8.	Megino-Luque, Cristina: 1 article (06/2022)
9.	Pamplona, Reinald: 1 article (06/2022)
10.	Piñol, Miquel: 1 article (06/2022)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2019 - "Human acireductone dioxygenase (HsARD), cancer and human health: Black hat, white hat or gray?" 11/01/2019 - "The 5'-methylthioadenosine (MTA) cycle-participating human acireductone dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its role remains unclear in hepatocellular carcinoma (HCC). "
2.	Infections 01/01/2020 - "Methionine adenosyltransferase 2B (MAT2B) and acireductone dioxygenase 1 (ADI1), which regulate HCC development and hepatitis C virus infection, respectively, were among the top 10 HCCPMs predicted by dBMHCC. " 04/01/2016 - "Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection."
3.	Carcinogenesis 08/01/2019 - "This review summarizes the relationships of the MSP enzyme acireductone dioxygenase (ARD), the ADI1 gene encoding ARD and other gene products (ADI1GP) with carcinomas and carcinogenesis. "
4.	Endometrial Neoplasms (Endometrial Cancer) 06/08/2022 - "Metabolomic Analysis Points to Bioactive Lipid Species and Acireductone Dioxygenase 1 (ADI1) as Potential Therapeutic Targets in Poor Prognosis Endometrial Cancer."
5.	Prostatic Neoplasms (Prostate Cancer) 11/01/2019 - "The 5'-methylthioadenosine (MTA) cycle-participating human acireductone dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its role remains unclear in hepatocellular carcinoma (HCC). "

Related Drugs and Biologics

1.	Matrix Metalloproteinase 14 (MT1-MMP)
2.	Methionine Adenosyltransferase
3.	Lipids
4.	Pemetrexed (MTA)
5.	myelencephalon-specific serine protease
6.	5'-methylthioadenosine