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insulin-like growth factor I-Pseudomonas exotoxin A (40)

IGFI fused to Pseudomonas exotoxin A; has antitumor effect on human glioblastoma multiforme cells

Also Known As:

IGF-I-PE40

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biological Toxins: 20
  - Exotoxins: 1439
    - insulin-like growth factor I-Pseudomonas exotoxin A (40): 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Somatomedins: 271
      - Insulin-Like Growth Factor I: 13099
        insulin-like growth factor I-Pseudomonas exotoxin A (40): 1

Related Diseases

1.	Neoplasms (Cancer) 01/01/1991 - "This protein, IGF-I-PE40, was cytotoxic to human cell lines derived from a variety of tumor types, with a breast carcinoma line (MCF-7) and two hepatoma lines (HEP3B and HEPG2) showing the highest sensitivity to the toxin. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1991 - "This protein, IGF-I-PE40, was cytotoxic to human cell lines derived from a variety of tumor types, with a breast carcinoma line (MCF-7) and two hepatoma lines (HEP3B and HEPG2) showing the highest sensitivity to the toxin. "
3.	Breast Neoplasms (Breast Cancer) 01/01/1991 - "This protein, IGF-I-PE40, was cytotoxic to human cell lines derived from a variety of tumor types, with a breast carcinoma line (MCF-7) and two hepatoma lines (HEP3B and HEPG2) showing the highest sensitivity to the toxin. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)