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brucine N-oxide

structure given in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yin, Wu: 3 articles (06/2006 - 10/2003)
2.	Cai, Bao-Chang: 2 articles (06/2006 - 10/2003)
3.	Yin, Fang-Zhou: 2 articles (06/2006 - 10/2003)
4.	Deng, Xu-Kun: 1 article (06/2006)
5.	Hua, Zi-Chun: 1 article (06/2006)
6.	Li, Wei-Dong: 1 article (06/2006)
7.	Lu, Xiao-Yu: 1 article (06/2006)
8.	Zhang, Xiao-Chun: 1 article (06/2006)
9.	Cai, Baochang: 1 article (05/2006)
10.	Deng, Xukun: 1 article (05/2006)

Related Diseases

1.	Pain (Aches) 10/01/2003 - "These results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and brucine N-oxide, biochemical mechanisms of brucine and brucine N-oxide are different even though they are similar in chemical structure." 10/01/2003 - "(Loganiaceae) as well as analgesic and anti-inflammatory activities of brucine and brucine N-oxide extracted from this medicinal plant, various pain and inflammatory models were employed in the present study to investigate their pharmacological profiles. "
2.	Hepatocellular Carcinoma (Hepatoma) 06/30/2006 - "To screen the anti-tumor effects of the four alkaloids: brucine, strychnine, brucine N-oxide and isostrychnine from the seed of Strychnos nux-vomica, MTT assay was used to examine the growth inhibitory effects of these alkaloids on human hepatoma cell line (HepG2). " 05/01/2006 - "In an attempt to dissect the mechanism of Strychnos nux-vomica, a commonly used Chinese folk medicine in the therapy of liver cancer, the cytotoxic effects of four alkaloids in Strychnos nux-vomica, brucine, brucine N-oxide, strychnine, and isostrychnine, on human hepatoma cells (HepG2) were screened by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrasolium bromide (MTT) assay. "
3.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 01/01/2022 - "The experimental autoimmune myasthenia gravis (EAMG) model in female Lewis rats, quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and enzyme-linked immunosorbent assay (ELISA) were performed to confirm the effect and mechanism of SS on MG. The following active compounds and hub targets were identified by screening and analyzing: isobrucine, vomicine, (S)-stylopine, strychnine, brucine-N-oxide, brucine and AKT1, MAPK1, MAPK14, CHRM1, ACHE, and CHRNA4. "
4.	Neoplasms (Cancer) 06/30/2006 - "To screen the anti-tumor effects of the four alkaloids: brucine, strychnine, brucine N-oxide and isostrychnine from the seed of Strychnos nux-vomica, MTT assay was used to examine the growth inhibitory effects of these alkaloids on human hepatoma cell line (HepG2). "
5.	Liver Neoplasms (Liver Cancer) 05/01/2006 - "In an attempt to dissect the mechanism of Strychnos nux-vomica, a commonly used Chinese folk medicine in the therapy of liver cancer, the cytotoxic effects of four alkaloids in Strychnos nux-vomica, brucine, brucine N-oxide, strychnine, and isostrychnine, on human hepatoma cells (HepG2) were screened by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrasolium bromide (MTT) assay. "

Related Drugs and Biologics

1.	brucine
2.	Analgesics (Analgesic Drugs)
3.	Strychnine
4.	Alkaloids
5.	Mitogen-Activated Protein Kinase 14
6.	Acetic Acid (Vinegar)
7.	Dinoprostone (PGE2)
8.	Serotonin (5 Hydroxytryptamine)
9.	Immunosorbents
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Traditional Medicine (Folk Remedies)