cynaropicrin

structure given in first source; RN given for ((3aR-(3aalpha,4alpha,6aalpha,8beta,9aalpha,9bbeta)))-isomer

Also Known As:

2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno(4,5-b)furan-4-yl ester

Networked: 27 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - cynaropicrin: 27
- Lactones: 1549
  - cynaropicrin: 27

Experts

1.	Adams, Michael: 4 articles (12/2015 - 11/2013)
2.	Hamburger, Matthias: 3 articles (03/2014 - 11/2013)
3.	Zimmermann, Stefanie: 3 articles (03/2014 - 11/2013)
4.	Usuki, Toyonobu: 2 articles (12/2015 - 03/2014)
5.	De Mieri, Maria: 2 articles (03/2014 - 11/2013)
6.	Kaiser, Marcel: 2 articles (03/2014 - 11/2013)
7.	Brun, Reto: 2 articles (11/2013 - 11/2013)
8.	Cho, Jae Youl: 2 articles (05/2004 - 01/2004)
9.	Jung, Jee H: 2 articles (05/2004 - 01/2004)
10.	Kim, Ae Ra: 2 articles (05/2004 - 01/2004)

Related Diseases

1.	Gastritis 01/01/2010 - "These results indicate that artichoke leaf extract is effective against acute gastritis and its beneficial effect is due to that of cynaropicrin. "
2.	Neoplasms (Cancer) 11/01/2023 - "Taken together, these results demonstrate that cynaropicrin causes potent inhibition of hematopoietic tumor cells in vitro and in vivo." 01/01/2020 - "Cynaropicrin also suppressed tumor growth in the xenograft model. " 05/25/2004 - "Cynaropicrin potently inhibited the proliferation of leukocyte cancer cell lines, such as U937, Eol-1 and Jurkat T cells, but some other cells such as Chang liver cells and human fibroblast cell lines were not strongly suppressed by cynaropicrin treatment. " 11/01/2023 - "In this study, we investigated the effects of cynaropicrin against multiple myeloma (MM) cells in vitro and assessed its in vivo effectiveness in a xenograft tumor zebrafish model. " 04/18/2017 - "Cultivated and/or spontaneous forms of CC studies have demonstrated that methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of leukocyte cancer cell. "
3.	Multiple Myeloma 11/01/2023 - "In this study, we investigated the effects of cynaropicrin against multiple myeloma (MM) cells in vitro and assessed its in vivo effectiveness in a xenograft tumor zebrafish model. " 11/01/2023 - "Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma."
4.	Hyperalgesia 11/01/2017 - "The results from the abdominal withdrawal reflex tests and electromyography recordings indicated that treatment with cynaropicrin significantly and dose-dependently alleviated the visceral hyperalgesia of PI-IBS rats (P<0.05). " 11/01/2017 - "In the present study, the analgesic effect of cynaropicrin and its underlying mechanism on the treatment of trinitrobenzene sulfonic (TNBS)-induced PI-IBS visceral hyperalgesia rats was investigated. "
5.	Body Weight (Weight, Body) 11/01/2013 - "Acute toxicity studies showed that one of two mice died at a cynaropicrin dose of 400 mg/kg of body weight given intraperitoneally (i.p.). "

Related Drugs and Biologics

1.	artichoke leaf
2.	Analgesics (Analgesic Drugs)
3.	Methanol (Carbinol)
4.	Sesquiterpenes
5.	Lactones
6.	Parasympatholytics (Antispasmodics)
7.	Galectin 3 (LGALS3)
8.	Cytochrome P-450 CYP1A1 (CYP1A1)
9.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
10.	Reactive Oxygen Species (Oxygen Radicals)