O-(biotinylcarbazoylmethyl)hydroxylamine

formed by reacting biotin hydrazide with O-(carboxymethyl)hydroxylamine in the presence of carbodiimide; used to tag AP sites in damaged DNA with biotin; structure given in first source

Also Known As:

aldehyde reactive probe; biotin-CMHA

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Biotin: 4061
        O-(biotinylcarbazoylmethyl)hydroxylamine: 2
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Biotin: 4061
    - O-(biotinylcarbazoylmethyl)hydroxylamine: 2

Experts

1.	Gates, Kent: 1 article (01/2010)
2.	Sun, Daekyu: 1 article (01/2010)
3.	Viswesh, Velliyur: 1 article (01/2010)
4.	Bulgar, Alina: 1 article (11/2009)
5.	Gerson, Stanton L: 1 article (11/2009)
6.	Liu, Lili: 1 article (11/2009)
7.	Somoza, Eduardo: 1 article (11/2009)
8.	Wang, Yanming: 1 article (11/2009)
9.	Wu, Chunying: 1 article (11/2009)
10.	Zhu, Wenxia: 1 article (11/2009)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2010 - "In the present study, we have determined the endogenous amount of AP sites and DNA strand breaks in genomic DNA and the amount of oxidative stress in a human pancreatic carcinoma cell line, MiaPaCa, treated with leinamycin by utilizing the aldehyde-reactive probe assay, the comet assay, and fluorescent probes, respectively. "
2.	Neoplasms (Cancer) 11/01/2009 - "Following induction of AP sites by temozolomide, both tumor models showed significant increase of [(11)C]MX uptake in tumor regions in terms of radioactivity concentration as a function of time, which correlates well with conventional aldehyde reactive probe (ARP)-based bioassays for AP sites."

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	DNA (Deoxyribonucleic Acid)
3.	leinamycin (DC 107)
4.	Temozolomide (Temodar)