HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
1,3,4-thiadiazol-2-ylcyanamide
effective against influenza A & B viruses; structure given in first source; RN givenrefers to the Na-salt; RN for parent cpd not available 5/91
Also Known As:
LY 217896; LY 253963; LY-217896; LY-253963; LY217896; LY253963
Networked:
4
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiazoles: 392
Thiadiazoles: 99
1,3,4-thiadiazol-2-ylcyanamide: 4
Nitriles: 227
1,3,4-thiadiazol-2-ylcyanamide: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
Thiadiazoles: 99
1,3,4-thiadiazol-2-ylcyanamide: 4
Related Diseases
1.
Human Influenza (Influenza)
07/01/1990 - "
The compound LY253963 (1,3,4-thiadiazol-2-ylcyanamide) inhibited the in vitro replication of representative influenza A and B viruses in Madin-Darby canine kidney (MDCK) cells at concentrations of 1-3.2 micrograms/ml. The yield of an influenza A (H3N2) virus in primary rhesus monkey kidney (RMK) cells was inhibited at 0.1-0.3 micrograms/ml. However, similar concentrations were inhibitory for the growth of uninfected MCDK or RMK cells.
"
05/01/1994 - "
The efficacy and safety of oral LY217896 for prevention of experimental influenza A/Kawasaki/86 (H1N1) virus infection were assessed in susceptible males randomly assigned to receive LY217896 (75 mg) or placebo once daily for 7 days beginning 24 h prior to viral challenge.
"
11/01/1990 - "
LY217896 (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus.
"
05/01/1994 - "
LY217896 was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.
"
11/01/1990 - "
1,3,4-Thiadiazol-2-ylcyanamide (LY217896) and its sodium salt were shown to be effective against influenza A and B viruses in vitro and in the mouse model.
"
2.
Paramyxoviridae Infections (Parainfluenza)
10/01/1990 - "
Toxicity and antiviral activity of LY253963 against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.
"
10/01/1990 - "
LY253963, the sodium salt of 1,3,4-thiadiazol-2-ylcyanamide, was evaluated in tissue culture and in cotton rats for toxicity and antiviral efficacy against respiratory syncytial (RSV) and parainfluenza type 3 (PIV3) viruses.
"
3.
Fever (Fevers)
11/01/1990 - "
In the ferret, LY217896 was effective in preventing fever induced by influenza virus.
"
4.
Virus Diseases (Viral Diseases)
07/01/1990 - "
In timing of additional studies, hemagglutinin expression was inhibited to the greatest extent when LY253963 exposure was begun at least 8 h before viral infection, which suggested either slow uptake or intracellular metabolism of LY253963 to an active form.
"
5.
Infections
05/01/1994 - "
Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans.
"
11/01/1990 - "
Mice treated initially with protective levels of LY217896 were resistant to a subsequent challenge of influenza virus in the absence of the compound, indicating that the animals were able to develop immunity to the initial infection.
"
05/01/1994 - "
The efficacy and safety of oral LY217896 for prevention of experimental influenza A/Kawasaki/86 (H1N1) virus infection were assessed in susceptible males randomly assigned to receive LY217896 (75 mg) or placebo once daily for 7 days beginning 24 h prior to viral challenge.
"
05/01/1994 - "
LY217896 was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.
"
Related Drugs and Biologics
1.
1,3,4-thiadiazol-2-ylcyanamide
2.
Sodium
3.
Salts
4.
Antiviral Agents (Antivirals)
5.
Hemagglutinins (Hemagglutinin)
6.
Drinking Water
7.
Cytostatic Agents
8.
Uric Acid (Urate)
9.
Rimantadine
10.
Ribavirin (Virazole)
Related Therapies and Procedures
1.
Intraperitoneal Injections