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oxetanocin G
inhibits human cytomegalovirus replication; structure given in first source
Also Known As:
OXT-G; 6H-Purin-6-one, 2-amino-9-(3,4-bis(hydroxymethyl)-2-oxetanyl)-1,9-dihydro-, (2R-(2alpha,3beta,4alpha))-
Networked:
6
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purinones: 2
Hypoxanthines: 1
Guanine: 1793
oxetanocin G: 6
Related Diseases
1.
Infections
08/01/1989 - "
Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice.
"
12/01/1990 - "
The results indicate that OXT-G was more potent and selective against GPCMV infection than DHPG.
"
12/01/1990 - "
Antiviral effect of oxetanocin G against guinea pig cytomegalovirus infection in vitro and in vivo.
"
01/01/1994 - "
Although further study of the toxicity of this compound would be essential before studies in man can be carried out, OXT-G has potent antiviral activity against WHV and may deserve evaluation as an antiviral agent in the treatment of chronic hepatitis B infections in humans.
"
07/01/1988 - "
The synthesis of HCMV-induced late polypeptides such as the 150,000-molecular-weight capsid and the 68,000-molecular-weight major matrix proteins was strongly suppressed when OXT-G (5 micrograms/ml) was added to the cultures at the beginning of infection.
"
2.
Chronic Hepatitis B
01/01/1994 - "
Although further study of the toxicity of this compound would be essential before studies in man can be carried out, OXT-G has potent antiviral activity against WHV and may deserve evaluation as an antiviral agent in the treatment of chronic hepatitis B infections in humans.
"
3.
Herpes Simplex
04/30/1991 - "
In this study we synthesized the triphosphate form of OXT-G, OXT-GTP, and examined its effect on the activities of HCMV DNA polymerase, herpes simplex type 2 (HSV-2) DNA polymerase and human DNA polymerase alpha.
"
4.
Body Weight (Weight, Body)
09/01/1992 - "
Mouse alpha interferon (200,000 U per injection, twice daily for 3 days) and a novel nucleoside, oxetanocin G (15 mg/kg of body weight per injection, twice daily for 7 days), inhibited viral DNA synthesis in the liver almost completely.
"
Related Drugs and Biologics
1.
Antiviral Agents (Antivirals)
2.
DNA-Directed DNA Polymerase (Polymerases, DNA)
3.
DNA Polymerase I (Klenow Fragment)
4.
oxetanocin guanosine triphosphate
5.
triphosphoric acid (triphosphate)
6.
Interferon-alpha (Interferon Alfa)
7.
Proteins (Proteins, Gene)
8.
Peptides (Polypeptides)
9.
Nucleosides
10.
Viral DNA