ardisiacrispin B

untero-contracting oleanane triterpene saponin form Ardisia crispa; structure given in first source

Also Known As:

3 beta -O-(alpha-L-rhamnopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-4)-(O-beta-D-glucopyranosyl-(1-2))-alpha-L-arabinopyranosyl)-16 alpha-hydroxy-13 beta,28-epoxyolean-30-al; Oleanan-29-al, 3- ((O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-4)-O-(beta-D-glucopyranosyl-(1-2))-alpha-L-arabinopyranosyl)oxy)-13,28-epoxy-16-hydroxy-, (3beta,16alpha,20beta)-

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Efferth, Thomas: 1 article (04/2018)
2.	Kuete, Victor: 1 article (04/2018)
3.	Mbaveng, Armelle T: 1 article (04/2018)
4.	Mbouangouere, Roukayatou: 1 article (04/2018)
5.	Ndontsa, Blanche L: 1 article (04/2018)
6.	Nguekeu, Yves M M: 1 article (04/2018)
7.	Tane, Pierre: 1 article (04/2018)
8.	Çelik, İlhami: 1 article (04/2018)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2018 - "Ardisiacrispin B displayed significant cytotoxic effects in the 9 tested cancer cell lines with IC50 values below 10 µM. " 04/01/2018 - "In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Taton (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes. " 04/01/2018 - "A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death."
2.	Leukemia 04/01/2018 - "The IC50 values ranges were 1.20 µM (towards leukemia CCRF-CEM cells) to 6.76 µM [against heptocarcinoma HepG2 cells] for ardisiacrispin B and 0.02 µM (against CCRF-CEM cells) to 122.96 µM (against resistant CEM/ADR5000 leukemia cells) for doxorubicin. "

Related Drugs and Biologics

1.	Saponins
2.	oleanane
3.	Triterpenes
4.	Doxorubicin (Adriamycin)