altertoxin I

structure given in first source; isolated from Alternaria species; do not confuse with Anemonia sulcata toxin I which is also abbreviated ATX I

Also Known As:

1,2,7,8,12b-pentahydro-1,4,6b,10-tetrahydroxyperylene-3,9-dione; altertoxin-1; 3,10-Perylenedione, 1,2,11,12,12a,12b-hexahydro-1,4,9,12a-tetrahydroxy-, (1S,12aR,12bS)-

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Anderson, Victoria M: 1 article (12/2021)
2.	Cichewicz, Robert H: 1 article (12/2021)
3.	Dai, Wentao: 1 article (12/2021)
4.	Haldar, Saikat: 1 article (12/2021)
5.	Houghton, Peter J: 1 article (12/2021)
6.	Loesgen, Sandra: 1 article (12/2021)
7.	Ma, Hongyan: 1 article (12/2021)
8.	Mooberry, Susan L: 1 article (12/2021)
9.	Overacker, Ross D: 1 article (12/2021)
10.	Risinger, April L: 1 article (12/2021)

Related Diseases

1.	Ewing Sarcoma (Sarcoma, Ewing) 12/07/2021 - "Altertoxin II, but not the related compounds altertoxin I and alteichin, was highly effective against every Ewing sarcoma cell line tested, with an average 25-fold selectivity for these cells as compared to cells representing other pediatric and adult cancers. "
2.	Neoplasms (Cancer) 12/07/2021 - "Altertoxin II, but not the related compounds altertoxin I and alteichin, was highly effective against every Ewing sarcoma cell line tested, with an average 25-fold selectivity for these cells as compared to cells representing other pediatric and adult cancers. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "Two variants of an extract from cultured Alternaria alternata, as well as the toxins alternariol (AOH), alternariol monomethyl ether (AME), altertoxin I (ATX-I), and altertoxin II (ATX-II), were tested singularly and in binary mixtures applying the 7-ethoxy-resorufin-O-deethylase (EROD) assay in MCF-7 breast cancer cells. "

Related Drugs and Biologics

1.	altertoxin II
2.	alteichin
3.	Cytochrome P-450 CYP1A1 (CYP1A1)
4.	alternariol monomethyl ether
5.	methylamphotericin B (AME)
6.	alternariol