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trimelamol
structure given in first source
Also Known As:
CB 10375; CB-10-375; N(2),N(4),N(6)-trihydroxymethyl-N(2),N(4),N(6)-trimethylmelamine; Methanol, (1,3,5-triazine-2,4,6-triyltris(methylimino))tris-
Networked:
10
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Triazines: 306
trimelamol: 10
Related Diseases
1.
Ovarian Neoplasms (Ovarian Cancer)
02/01/1991 - "
Phase II trial of trimelamol in refractory ovarian cancer.
"
02/01/1991 - "
The role of Trimelamol in the treatment of ovarian cancer remains to be defined, but its activity is limited in refractory disease.
"
02/01/1991 - "
Trimelamol is an analogue of hexamethymelamine which exhibited activity against refractory ovarian cancer in phase I clinical trial.
"
01/01/1986 - "
Superior efficacy of trimelamol to hexamethylmelamine in human ovarian cancer xenografts.
"
01/01/1986 - "
A series of eight human ovarian cancer lines grown in nude mice were used to compare the activity of hexamethylmelamine (HMM) and N2,N4,N6-trihydroxy methyl-N2,N4,N6-trimethylmelamine (trimelamol).
"
2.
Vomiting
05/01/1986 - "
PMM caused dose-limiting emesis and sedation whereas Trimelamol is much less neurotoxic in rodents.
"
07/01/1996 - "
Trimelamol (TM) was developed as a water soluble analogue of the oral chemotherapeutic agent hexamethyl-melamine (HMM), to be administered i.v., in an effort to avoid dose limiting emesis.
"
11/01/1988 - "
BRL 43694 also substantially reduced the vomiting induced by cyclophosphamide:doxorubicin, and prevented the trimelamol-induced emesis.
"
3.
Neoplasms (Cancer)
01/01/1986 - "
Trimelamol appeared to be more active than HMM and achieved a T/C below 25% in seven tumor lines.
"
12/24/1993 - "
Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.
"
4.
Plasmacytoma
01/01/1986 - "
Trimelamol had similar activity to PMM against the murine PC6 plasmacytoma, but enhanced activity with respect to PMM against the Walker 256 carcinosarcoma in the rat, a species which metabolizes PMM less efficiently.
"
5.
Carcinosarcoma
01/01/1986 - "
Trimelamol had similar activity to PMM against the murine PC6 plasmacytoma, but enhanced activity with respect to PMM against the Walker 256 carcinosarcoma in the rat, a species which metabolizes PMM less efficiently.
"
Related Drugs and Biologics
1.
Altretamine (Hemel)
2.
Triazines
3.
melamine
4.
Granisetron (Kytril)
5.
Glutathione (Reduced Glutathione)
6.
Formaldehyde (Formol)
7.
Doxorubicin (Adriamycin)
8.
Cyclophosphamide (Cytoxan)
9.
PC6 extract (PC6)