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RS 43179 (lonapalene)
used in treatment of psoriasis
Also Known As:
lonapalene
; 6-chloro-2,3-dimethoxynaphthalene-1,4-diol diacetate; RS-43179
Networked:
5
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
RS 43179: 5
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
RS 43179: 5
Related Diseases
1.
Inflammation (Inflammations)
01/01/1992 - "
However, topically a number of agents have shown promise for skin inflammation, with Syntex's lonapalene the most advanced of these.
"
06/01/1990 - "
Topical application of this compound blocked arachidonic acid and 12-O-tetradecanoylphorbol ester-induced mouse skin inflammation with activity comparable to that observed for lonapalene.
"
2.
Psoriasis (Pustulosis Palmaris et Plantaris)
07/01/1990 - "
The pharmacologic and clinical effects of the 5-lipoxygenase inhibitor, lonapalene, have been determined in a double-blind, placebo-controlled, topical study in ten volunteers with psoriasis.
"
07/01/1990 - "
This and the selectivity of the pharmacologic response suggest that the therapeutic effect of topical lonapalene in psoriasis might be related to inhibition of leukotriene B4 synthesis.
"
11/01/1988 - "
A series of 2,3-(alkylidenedioxy)naphthalene (5a-p) analogues of lonapalene (RS-43179, 1), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity against arachidonic acid induced mouse ear edema.
"
09/01/1992 - "
The percutaneous absorption and metabolism of lonapalene (6-chloro-2,3-dimethoxynaphthalene-1,4-diol-diacetate; RS-43179), a topically effective 5-lipoxygenase inhibitor, has been measured in six subjects with stable plaque-type psoriasis of the lower extremities.
"
07/01/1990 - "
Pharmacologic and clinical effects of lonapalene (RS 43179), a 5-lipoxygenase inhibitor, in psoriasis.
"
3.
Edema (Dropsy)
11/01/1988 - "
A series of 2,3-(alkylidenedioxy)naphthalene (5a-p) analogues of lonapalene (RS-43179, 1), a 5-lipoxygenase inhibitor currently under clinical investigation for the treatment of psoriasis, has been prepared and evaluated for topical inhibitory activity against arachidonic acid induced mouse ear edema.
"
Related Drugs and Biologics
1.
Lipoxygenase Inhibitors
2.
RS 43179 (lonapalene)
3.
Arachidonic Acid (Vitamin F)
4.
Therapeutic Uses
5.
Leukotriene B4
6.
Esters