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trimethylchlorosilane
Also Known As:
chlorotrimethylsilane
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organosilicon Compounds: 15
Trimethylsilyl Compounds
trimethylchlorosilane: 1
Related Diseases
1.
Dehydration (Water Stress)
04/17/1998 - "
As a model study, conjugate addition of 4-(trimethylsilyl)-3-butynylmagnesium chloride to enone 7 followed by trapping of the enolate with chlorotrimethylsilane gave trimethysilyl enol ether 8. Iodination of 8 with a mixture of NaI and m-CPBA afforded iodo ketone 6. Radical cyclization of 6 effected by Bu(3)SnH and AIBN gave 5. Epoxidation of 5 with m-CPBA yielded epoxy ketone 9. Desilylation and rearrangement of 9 by formic acid gave aldehyde 4. Aldol condensation and dehydration furnished angular triquinane skeleton 3. Total synthesis of (-)-5-oxosilphiperfol-6-ene (1) was accomplished in 12 steps starting from keto ester 14 based on this route.
"
Related Drugs and Biologics
1.
Ketones
2.
Ether (Diethyl Ether)
3.
Esters
4.
Chlorides
5.
Aldehydes
6.
3-hydroxybutanal (aldol)
7.
formic acid (formate)
8.
azobis(isobutyronitrile) (AIBN)
9.
3-chloroperbenzoic acid (meta-chloroperoxybenzoic acid)