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mopidralazine
Also Known As:
MDL 899; MDL-899; N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine; mopidralazine hydrochloride; 3-Pyridazinamine, N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-, monohydrochloride
Networked:
3
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
mopidralazine: 3
Related Diseases
1.
Essential Hypertension
09/01/1985 - "
In a combined drug regimen, MDL-899 is an effective vasodilator drug that significantly improved the blood pressure control of patients with essential hypertension.
"
09/01/1985 - "
Clinical evaluation of the vasodilator MDL-899 in patients with essential hypertension.
"
09/01/1985 - "
In this study of 10 patients with essential hypertension inadequately controlled by standard beta-blocker-diuretic combination therapy, the addition of 5 mg of MDL-899, a peripheral arteriolar vasodilator, resulted in significant reductions in blood pressure, both supine and standing, which was maximal 4-8 h after dosing, with no additional orthostatic component.
"
2.
Tachycardia (Tachyarrhythmias)
07/01/1983 - "
Atenolol increased the hypotensive effect and attenuated the tachycardia following MDL-899 alone.
"
07/01/1983 - "
Side effects following MDL-899 administration included headache, lightheadedness, and tachycardia.
"
3.
Hypertension (High Blood Pressure)
01/01/1986 - "
MDL-899 is new phthalazine derivative which has been developed as a substitute for hydralazine, which has several undesirable effects, in the treatment of hypertension.
"
4.
Headache (Headaches)
07/01/1983 - "
Side effects following MDL-899 administration included headache, lightheadedness, and tachycardia.
"
5.
Dizziness (Lightheadedness)
07/01/1983 - "
Side effects following MDL-899 administration included headache, lightheadedness, and tachycardia.
"
Related Drugs and Biologics
1.
Vasodilator Agents (Vasodilators)
2.
Diuretics
3.
Hydralazine (Apresoline)
4.
Atenolol (Tenormin)
5.
phthalazine
Related Therapies and Procedures
1.
Therapeutics