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iodothiouracil
Also Known As:
5-iodo-2-thiouracil; iodothiouracil sodium
Networked:
6
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidinones: 71
Uracil: 1493
Thiouracil: 476
iodothiouracil: 6
Related Diseases
1.
Melanoma (Melanoma, Malignant)
07/01/1986 - "
Iodothiouracil as a melanoma localizing agent.
"
01/01/1992 - "
Previous studies on mice carrying melanoma have shown that 5-iodo-2-thiouracil (ITU) is accumulated in the tumours due to its specific incorporation into melanin during its synthesis.
"
06/01/1991 - "
To be clinically useful in melanoma scanning, thiouracil has been radioiodinated, and 5-iodo-2-thiouracil (ITU) was found to be localized in melanotic melanoma as selectively as thiouracil.
"
01/01/1989 - "
5-Iodo-2-thiouracil (ITU) is of interest due to its ability to bind specifically to the pigment melanin during melanogenesis and is of potential value in the diagnosis and treatment of malignant melanoma.
"
07/01/1986 - "
The variety of iodine isotopes available makes iodothiouracil a particularly promising melanoma-localizing agent.
"
2.
Hyperthyroidism
09/01/1951 - "
Therapeutic studies in hyperthyroidism: sodium 5-iodo-2-thiouracil.
"
3.
Thyrotoxicosis
03/03/1955 - "
[Potassium perchlorate and iodothiouracil in thyrotoxicosis].
"
4.
Neoplasms (Cancer)
07/01/1986 - "
Tumor uptake and biodistribution of [35S]thiouracil and iodothiouracil (both iodine-127 (127I) and iodine-125 (125I) labeled) have been compared and were found to be essentially the same.
"
5.
Neoplasm Metastasis (Metastasis)
07/01/1986 - "
Iodothiouracil was also shown to localize in remote secondary metastases using a metastatic variant of the Harding-Passey melanoma currently being developed in our laboratory.
"
Related Drugs and Biologics
1.
Melanins (Melanin)
2.
Sodium
3.
Thiouracil
4.
Iodine Isotopes
5.
Iodine
6.
potassium perchlorate