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2,4,5-trimethylaniline

RN given refers to parent cpd

Also Known As:

2,4,5-TMA; 2,4,5-trimethylaniline hydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - 2,4,5-trimethylaniline: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1979 - "Because historical records of this laboratory for control B6C3F1 male mice show a relatively high incidence of hepatocellular carcinomas, an increased incidence of these tumors in 2,4,5-trimethylaniline dosed male mice as compared with matched controls could not be clearly associated with administration of the test compound. " 11/01/1978 - "2,4-Toluenediamine, o-phenylenediamine, o-toluidine, 2,4,6-trimethylaniline, 2,4,5-trimethylaniline, 2,5-xylidine, and 1-chloro-2-nitrobenzene led to tumors in one or more tissues in all three of these animal models. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1979 - "It is concluded that under the conditions of this bioassay, 2,4,5-trimethylaniline was carcinogenic for male and female F344 rats and female B6C3F1 mice, inducing hepatocellular carcinomas or neoplastic nodules in the rats of each sex, alveolar/bronchiolar carcinomas in the female rats, and hepatocellular carcinomas in female mice." 01/01/1979 - "Because historical records of this laboratory for control B6C3F1 male mice show a relatively high incidence of hepatocellular carcinomas, an increased incidence of these tumors in 2,4,5-trimethylaniline dosed male mice as compared with matched controls could not be clearly associated with administration of the test compound. "
3.	Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar) 01/01/1979 - "It is concluded that under the conditions of this bioassay, 2,4,5-trimethylaniline was carcinogenic for male and female F344 rats and female B6C3F1 mice, inducing hepatocellular carcinomas or neoplastic nodules in the rats of each sex, alveolar/bronchiolar carcinomas in the female rats, and hepatocellular carcinomas in female mice."

Related Drugs and Biologics

1.	1,2-diaminobenzene (o-phenylenediamine)
2.	2-chloronitrobenzene (ONCB)
3.	2-toluidine (o-toluidine)
4.	2,4,6-trimethylaniline
5.	2,4-diaminotoluene