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4-hydroxymercuribenzoate
Also Known As:
PHMB cpd; p-hydroxymercuribenzoate; p-hydroxymercuribenzoic acid; p-hydroxymercury benzoate; para-hydroxymercuribenzoate; sodium p-hydroxymercury benzoate
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Hydroxybenzoates: 18
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Benzoates: 426
Hydroxybenzoates: 18
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Mercuribenzoates: 1
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxybenzoates: 18
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Carbocyclic Acids
Benzoates: 426
Hydroxybenzoates: 18
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Mercuribenzoates: 1
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Organometallic Compounds: 64
Organomercury Compounds: 3
Phenylmercury Compounds
Mercuribenzoates: 1
Hydroxymercuribenzoates
4-hydroxymercuribenzoate: 7
Related Diseases
1.
Hyperglycemia
01/01/1979 - "
Hyperglycemia following p-hydroxymercuribenzoate administration to mice.
"
01/01/1979 - "
p-Hydroxymercuribenzoate (PMB) administration to fed mice induced transient hyperglycemia of a few hours' duration, and an increase in mitochondrial volume and pyroantimonate precipitation in the cytoplasmic ground substance of the pancreatic islet B-cells, whereas the secretory granules were unaffected.
"
10/01/1979 - "
The aims were to see whether p-hydroxymercuribenzoate (PMB) administration affects the serum insulin concentration in mice in vivo, whether the transitory hyperglycemia induced in fed mice by treatment with PMB is affected by L-leucine, tolbutamide, D-mannoheptulose or insulin, and whether PMB affects the B-cell toxicity of alloxan.
"
10/01/1979 - "
p-Hydroxymercuribenzoate-induced hyperglycemia: influence of pre- and post-treatment with L-leucine, tolbutamide, D-mannoheptulose, insulin and alloxan.
"
2.
Mastocytoma
09/01/1971 - "
Activation of mouse mastocytoma ATP sulfurylase by p-hydroxymercuribenzoate.
"
3.
Sexually Transmitted Diseases (Sexually Transmitted Disease)
04/01/1980 - "
This protease activity was inhibited by soybean trypsin inhibitor (STI), benzamidine and (p-nitrophenyl)-p'-guanidinobenzoate (NPGB), and was insensitive to 1-chloro-3-tosylamido-7-amino-2-heptanone (TLCK) and p-hydroxymercuribenzoic acid (HMB).
"
4.
Hypothermia
12/01/1986 - "
Accumulation of cimetidine was against a concentration gradient via a saturable process (Km = 53 microM, Vmax = 12 nmol/ml/min) that was inhibited by sulfhydryl reagents (p-hydroxymercuribenzoate), metabolic inhibitors (KCN and 2,4-dinitrophenol) and hypothermia (Q10 = 4.5), but did not require inward Na+ gradient.
"
5.
Hepatocellular Carcinoma (Hepatoma)
09/01/1984 - "
Incubation of Novikoff rat hepatoma cells; mouse L929, P388 and L1210 cells; and Chinese hamster ovary cells with sulfhydryl reagents, such as p-hydroxymercuribenzoate or p-hydroxymercuribenzenesulfonate, reduced the zero-trans influx of uridine in a concentration-dependent manner.
"
Related Drugs and Biologics
1.
Sulfhydryl Reagents
2.
2,4-Dinitrophenol (2,4 Dinitrophenol)
3.
Uridine
4.
Trypsin Inhibitors
5.
Tosyllysine Chloromethyl Ketone
6.
Tolbutamide (Orinase)
7.
Sulfate Adenylyltransferase (ATP Sulfurylase)
8.
Peptide Hydrolases (Proteases)
9.
Nucleotidyltransferases
10.
Mannoheptulose