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poly-N(5)-(2-hydroxyethyl)glutamine
Also Known As:
PHEG; poly-alpha-(N(5)-(2-hydroxyethyl)-L-glutamine)
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
poly-N(5)-(2-hydroxyethyl)glutamine: 3
Related Diseases
1.
Cardiotoxicity
01/01/1991 - "
On the other hand, a decrease in total toxicity and cardiotoxicity resulting from the linkage of DNR and PHEG, the therapeutic efficacy being preserved, stimulates the efforts to find a suitable polymer carrier of anthracyclines without more serious side-effects.
"
2.
Neoplasms (Cancer)
02/01/1999 - "
The results indicate that the PHEG-Gly-Phe-Ala-Leu-PDM conjugate is a promising candidate for cancer treatment.
"
01/01/1984 - "
The injections of 3.2 mg (equivalent ara-C per kg) of ara-C:PHEG showed a moderate antitumor activity with an ILS of 113% which was similar to the ILS (119%) found when unconjugated ara-C (400 mg/kg) was used to treat tumor-bearing mice.
"
3.
Plasmacytoma
01/01/1991 - "
The linkage of DNR and PHEG did not markedly change the therapeutic activity in three murine hemoblastoses--plasmacytoma MOPS 406, leukemia P388 and hemoblastosis La.
"
4.
Leukemia P388
01/01/1991 - "
The linkage of DNR and PHEG did not markedly change the therapeutic activity in three murine hemoblastoses--plasmacytoma MOPS 406, leukemia P388 and hemoblastosis La.
"
5.
Body Weight (Weight, Body)
02/01/1999 - "
The PHEG-Gly-Phe-Ala-Leu-PDM conjugate, which is rapidly degraded by lysosomal and tumour-associated enzymes also showed a decreased systemic toxicity in vivo and could be administered at a dose of 8 mg PDM/kg body weight intravenously, compared with just 2 mg/kg for free PDM.
"
Related Drugs and Biologics
1.
Anthracyclines
2.
Polymers
3.
Enzymes
4.
Cytarabine (Cytosar-U)
5.
glycylphenylalanine
6.
morpholinopropane sulfonic acid (MOPS)
Related Therapies and Procedures
1.
Injections