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3,4-epoxy-1-butene
RN given refers to monomer
Also Known As:
1,2-EB; 1,2-epoxybutene; 1,2-epoxybutene-3; butadiene monoepoxide; butadiene monoxide; butadiene oxide; butadienemonoepoxide; homopolymer of 3,4-epoxy-1-butene; oxirane, ethenyl-; vinyl oxirane
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ethers: 242
Cyclic Ethers: 12
Epoxy Compounds: 689
3,4-epoxy-1-butene: 6
Experts
1.
Hu, Y
: 1 article (03/2007)
2.
Kligerman, A D
: 1 article (03/2007)
Related Diseases
1.
Chromosome Aberrations (Chromosome Abnormalities)
01/01/1986 - "
Butadiene monoxide, which previously has not been tested in a mammalian system, was determined to be a very effective inducer of sister chromatid exchanges and chromosome aberrations.
"
03/20/2007 - "
In a series of in vitro experiments, lymphocytes from rats, mice, and humans were exposed to 3,4-epoxy-1-butene (EB) or 1,2:3,4-diepoxybutane (DEB) for 1h at the G(0) stage of the cell cycle, stimulated to divide, and cultured to assess the ability of these metabolites to induce sister chromatid exchange (SCE) and chromosome aberrations (CAs).
"
07/21/1999 - "
3,4-epoxy-1-butene (EB), a primary metabolite of butadiene, is a direct-acting "S-dependent" genotoxicant that can induce sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) in cycling cells in vitro.
"
01/01/1986 - "
Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide.
"
2.
Carcinogenesis
01/01/1987 - "
Inhalation pharmacokinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis.
"
3.
Neoplasms (Cancer)
02/01/1998 - "
1,3-Butadiene (BD), a compound used extensively in the rubber industry, is weakly carcinogenic in Sprague-Dawley rats after chronic exposures to concentrations of 1000 and 8000 ppm. Conversely, in B6C3F1 mice, tumors occur after chronic exposures to concentrations as low as 6.25 ppm. Previously, we have shown that tissue concentrations of the mutagenic BD metabolites, butadiene monoepoxide (BDO) and butadiene diepoxide (BDO2), are present in greater concentrations in mice than in rats following acute exposures to low levels (100 ppm or less).
"
4.
Body Weight (Weight, Body)
01/01/1991 - "
The data obtained were used to extrapolate on the total rate of butadiene monoxide metabolism for each species in vivo: it was calculated to be 1.3 times higher in mice and 2.3 times lower in man compared to rats, when corrected for body weight.
"
Related Drugs and Biologics
1.
1,3-butadiene (divinyl)
2.
diepoxybutane
3.
Styrene (Styrol)
4.
Acrylonitrile