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Glu-P-2
RN given refers to parent cpd
Also Known As:
2-aminodipyrido(1,2-a-3',2'-d)imidazole; 2-aminodipyridoimidazole; Glu P-2; Glu-P-2, monohydrobromide
Networked:
8
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Glu-P-2: 8
Related Diseases
1.
Chromosome Aberrations (Chromosome Abnormalities)
09/01/1992 - "
Glu-P-2, IQ, MeIQ, harman, and harmine did not induce chromosome aberrations by themselves at the concentrations used in this study.
"
09/01/1992 - "
A alpha C, MeA alpha C, Glu-P-1, Glu-P-2, IQ, MeIQ, harman and harmine increased chromosome aberrations only in the presence of S9 mix.
"
11/01/1991 - "
Intraperitoneal injections of Trp-P-1, Glu-P-1, MeIQx, IQ and nitro-IQ resulted in chromosome aberrations in up to 16% of the metaphase cells and SCEs at up to 0.9 per chromosome, while injections of Trp-P-2 and Glu-P-2 produced SCEs at up to 0.7 and 1.1 per chromosome, respectively.
"
2.
Neoplasms (Cancer)
03/01/1984 - "
Glu-P-2 produced tumors in the same sites at slightly lower incidence.
"
07/01/1988 - "
Statistical analysis revealed that the incidences of the lung tumor in the mice given Glu-P-1 or Glu-P-2 and that of liver tumor in the male mice given Glu-P-2 25 mg/kg body wt were significantly higher than those of controls.
"
01/01/1984 - "
There were no marked differences between the tumors induced by Glu-P-1 and Glu-P-2.
"
01/01/1984 - "
Details of the morphologic features of the intestinal tumors induced in F344 rats by Glu-P-1 and Glu-P-2 are described.
"
03/01/1984 - "
The multipotent carcinogenicities of Glu-P-1 and Glu-P-2 in rats and mice suggest that heterocyclic amines present in cooked food may be important in the development of human cancer.
"
3.
Carcinogenesis
09/01/1987 - "
Trp-P-1, Trp-P-2, MeA alpha C, A alpha C, Glu-P-1, Glu-P-2, Lys-P-1, IQ and Phe-P-1 were tested for tumour initiating activity in a two-stage skin carcinogenesis model using 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter.
"
4.
Sarcoma (Soft Tissue Sarcoma)
08/01/1986 - "
Hemangioendothelial sarcomas were also induced by Glu-P-1, Glu-P-2, MeA alpha C, and A alpha C.
"
5.
Hepatocellular Carcinoma (Hepatoma)
08/01/1986 - "
In rats, hepatocellular carcinomas were induced by Trp-P-1, Glu-P-1, Glu-P-2, and IQ.
"
Related Drugs and Biologics
1.
Harmine (Telepathine)
2.
2- amino- 3,4- dimethylimidazo(4,5- f)quinoline (MeIQ)
3.
harman (harmane)
4.
2- amino- 6- methyldipyrido(1,2- a- 3',2'- d)imidazole
5.
3- amino- 1,4- dimethyl- 5H- pyrido(4,3- b)indole
6.
Amines
7.
3-amino-1-methyl-5H-pyrido(4,3-b)indole
8.
Carcinogens
9.
2-nitro-3-methylimidazo(4,5-f)quinoline
10.
imidazole
Related Therapies and Procedures
1.
Intraperitoneal Injections
2.
Injections