phyllanthoside

structure

Also Known As:

beta-D-Glucopyranose, 2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-, 3-acetate 1-(decahydro-5''-methyl-4''-((1-oxo-3-phenyl-2-propenyl)oxy)dispiro(oxirane-2,3'(2'H)-benzofuran-2',2''-(2H)pyran)-6'-carboxylate), (2'S-(2'alpha(4''R*(E),5''S*),3'beta,3'aalpha,6'alpha,7'aalpha))-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - phyllanthoside: 3
Carbohydrates: 22023
- Glycosides: 2119
  - phyllanthoside: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - phyllanthoside: 3
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - phyllanthoside: 3
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - phyllanthoside: 3

Related Diseases

1.	Rhabdomyosarcoma 01/01/1989 - "Concentrations of phyllanthoside and metabolite required to inhibit cell-colony formation by human A204 rhabdomyosarcoma in vitro were 0.47 nM and 24 microM, respectively. " 01/01/1986 - "Coculture with isolated hepatocytes decreased the cytotoxicity of phyllanthoside to A204 human rhabdomyosarcoma cell line growing in soft agarose. "
2.	Neoplasms (Cancer) 01/01/1986 - "Phyllanthoside is a naturally occurring glycoside with activity against IP transplantable murine tumors. "
3.	Melanoma (Melanoma, Malignant) 07/12/1985 - "Phyllanthoside is a glycoside isolated from the roots of the Central American tree Phyllanthus acuminatus Vahl with antitumor activity against murine B-16 melanoma and P-388 leukemia. "
4.	Leukemia 07/12/1985 - "Phyllanthoside is a glycoside isolated from the roots of the Central American tree Phyllanthus acuminatus Vahl with antitumor activity against murine B-16 melanoma and P-388 leukemia. "
5.	Ataxia (Dyssynergia) 01/01/1986 - "The highest nontoxic dose of phyllanthoside in dog was 0.1 mg/kg, while doses of 0.5 mg/kg and 3.0 mg/kg resulted in ataxia and death of the dog. "

Related Drugs and Biologics

1.	Glycosides
2.	Sepharose (Agarose)