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amoscanate
structure; RN given refers to parent cpd
Also Known As:
4-isothiocyanato-4'-nitrodiphenylamine; 4-isothiocyanato-N-(4-nitrophenyl)benzenamine; C 9333-Go; C-9333-Go; CGP 4540; CGP-4540; nithiocyamine; nithiocyanamine
Networked:
24
relevant articles (
7
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Aniline Compounds: 46
Diphenylamine: 109
amoscanate: 24
Isocyanates: 512
Isothiocyanates: 501
amoscanate: 24
Sulfur Compounds: 278
Isothiocyanates: 501
amoscanate: 24
Related Diseases
1.
Infections
09/01/1983 - "
Efficacy of amoscanate against experimental schistosomal infections in monkeys.
"
12/01/1983 - "
Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections.
"
06/01/1989 - "
japonicum were treated with praziquantel or amoscanate 7 or 8 weeks after infection.
"
06/01/1986 - "
Worms that had been subjected to amoscanate or hycanthone in the third week after infection showed evidence of this as adults in having a reduced fecundity.
"
09/01/1980 - "
The efficacy of amoscanate (C9333-Go/CGP 4540) on filarial infections of Mastomys natalensis.
"
2.
Schistosomiasis (Bilharziasis)
01/01/1985 - "
These data suggest that the immunogenicity of Amoscanate is readily detected; furthermore, since there is no lasting immunity to schistosomiasis, thus necessitating multiple administration of the drug, the possibility that serum antibody titers to Amoscanate may interfere with its therapeutic efficacy cannot be overlooked.
"
07/01/1983 - "
[Efficacy of amoscanate derivatives in experimental schistosomiasis].
"
02/01/1983 - "
[Studies on the elimination of nithiocyamine from patients with schistosomiasis and its toxicities to the liver-bile system of rats].
"
09/01/1986 - "
These results suggest that this formulation of amoscanate, at 1 mg/kg, is sufficiently well tolerated and safe to justify evaluation for efficacy in patients with schistosomiasis.
"
3.
Schistosomiasis mansoni
11/01/1983 - "
Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice.
"
11/01/1983 - "
Amoscanate (0.1% w/v) in methanol solution applied to skin by tail immersion 1 day prior to cercarial exposure provided mice with better than 90% protection against mature Schistosoma mansoni infections.
"
4.
Hookworm Infections (Hookworm Infection)
01/01/1977 - "
A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection.
"
01/01/1977 - "
9333 Go./CGP 4540 in human hookworm infection.
"
07/01/1977 - "
A new compound, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), was tried in 39 hospitalized patients with hookworm infection, using several treatment schedules.
"
07/01/1977 - "
Clinical trials of a new anthelmintic, 4-isothiocyanato-4'-nitrodiphenylamine (C.9333-Go/CGP 4540), for the cure of hookworm infection.
"
5.
Body Weight (Weight, Body)
01/01/1993 - "
Amoscanate, a substance which damages photoreceptors, was administered orally to Wistar rats in doses of 10, 40, and 125 mg/kg body weight once daily for 3 or 10 days.
"
06/01/1985 - "
Mastomys natalensis were infected percutaneously with 250 cercariae of Schistosoma mansoni and treated effectively with 5 X 50 mg amoscanate/kg body-weight 12-16 (I), 28-32 (II), 56-60 (III) and 101-105 days p.i. (IV) respectively.
"
02/01/1986 - "
In the animal-mediated assays the same ranking order of genotoxic activity was observed, but the exposure levels required to produce significant genotoxic effects in vivo were (substantially) higher than in the in vitro tests: SQ 18 506 was active at 0.1 mg/kg body weight, metronidazole at 4 mg/kg, and amoscanate at dosages higher than 10 mg/kg. In host-mediated assays the highest genotoxic activity for all three chemicals was observed in organs of the gastro-intestinal tract (usually in the stomach).
"
Related Drugs and Biologics
1.
amoscanate
2.
Anthelmintics
3.
Albendazole (Albenza)
4.
Solutions
5.
Mebendazole (Anti-Worm)
6.
Fenbendazole
7.
Benzimidazoles
8.
Methanol (Carbinol)
9.
flubendazole
10.
oxibendazole
Related Therapies and Procedures
1.
Aftercare (After-Treatment)