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benzo(a)pyrene 4,5-epoxide
RN given refers to cpd with unspecifiedisomeric designation
Also Known As:
3b,4a-dihydrobenzo(1,2)pyreno(4,5-b)oxirene; 4,5-dihydro-4,5-epoxybenzo(a)pyrene; benzo(a)pyrene 4,5-epoxide, (+-)-isomer; benzo(a)pyrene 4,5-oxide
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
Benzopyrenes: 67
benzo(a)pyrene 4,5-epoxide: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
Benzopyrenes: 67
benzo(a)pyrene 4,5-epoxide: 2
Related Diseases
1.
Carcinogenesis
06/01/1979 - "
The enzymatic systems responsible for the metabolism and excretion of benzo(a)pyrene 4,5-oxide remained viable in the isolated perfused liver for at least 60 min. The toxicological significance of the release of polycyclic aromatic hydrocarbon metabolites from the liver into the vascular circulation and the possible significance of UDP:glucuronyltransferase activity in preventing chemically induced carcinogenesis are discussed.
"
2.
Hepatocellular Carcinoma (Hepatoma)
05/01/1985 - "
Microsomal epoxide hydrolase activity in rat H4-II-E hepatoma cells was refractory to induction, except by trans-stilbene oxide treatment, which caused a 70% increase in benzo[a]pyrene 4,5-oxide hydrolase activity.
"
Related Drugs and Biologics
1.
Uridine Diphosphate (UDP)
2.
Glucuronosyltransferase (UDP Glucuronosyltransferase)
3.
Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
4.
Hydrolases
5.
Epoxide Hydrolases
6.
stilbene oxide