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Poliovirus 3C protease

Also Known As:

3C protease, Poliovirus; 3C proteinase, Poliovirus; poliovirus 3CD proteinase; poliovirus 3c proteinase; proteinase 3C, Poliovirus

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Cysteine Proteases: 1964
        Cysteine Endopeptidases: 4
        3C Viral Proteases: 11
        Poliovirus 3C protease: 3
      - Viral Proteases: 35
        3C Viral Proteases: 11
        Poliovirus 3C protease: 3
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Viral Proteins: 4250
    - Viral Nonstructural Proteins: 70
      - Viral Proteases: 35
        3C Viral Proteases: 11
        Poliovirus 3C protease: 3

Experts

1.	Lloyd, Richard E: 2 articles (03/2015 - 11/2007)
2.	Doyle, Nicole: 1 article (01/2016)
3.	Goodfellow, Ian G: 1 article (01/2016)
4.	Humoud, Majid N: 1 article (01/2016)
5.	Langereis, Martijn A: 1 article (01/2016)
6.	Locker, Nicolas: 1 article (01/2016)
7.	Roberts, Lisa O: 1 article (01/2016)
8.	Royall, Elizabeth: 1 article (01/2016)
9.	Sorgeloos, Frederic: 1 article (01/2016)
10.	Willcocks, Margaret M: 1 article (01/2016)

Related Diseases

1.

11/15/2007 - "Infection resulted in cleavage of G3BP, but not TIA-1 or TIAR, by poliovirus 3C proteinase. "
03/01/2015 - "We previously showed that poliovirus 3C proteinase cleaves the SG-nucleating protein G3BP1, blocking the ability of cells to form SGs late in infection. "
01/01/2016 - "FCV infection resulted in the cleavage of the SG-nucleating protein Ras-GTPase activating SH3 domain-binding protein (G3BP1), which is mediated by the viral 3C-like proteinase NS6(Pro) Using mutational analysis, we identified the FCV-induced cleavage site within G3BP1, which differs from the poliovirus 3C proteinase cleavage site previously identified. "

Related Drugs and Biologics

1.	GTP Phosphohydrolases (GTPases)
2.	ras Proteins
3.	Proteins (Proteins, Gene)
4.	Peptide Hydrolases (Proteases)
5.	Carrier Proteins (Binding Protein)