steppogenin

isolated from Cudrania tricuspidata

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 01/01/2023 - "These results suggest that the natural compound steppogenin could potentially be used to treat angiogenic diseases, such as those involving solid tumors, because of its dual inhibition of HIF-1α and DLL4." 01/01/2023 - "Steppogenin suppresses tumor growth and sprouting angiogenesis through inhibition of HIF-1α in tumors and DLL4 activity in the endothelium." 01/01/2023 - "In tumor cells and retinal pigment epithelial cells, steppogenin significantly suppressed HIF-1α protein levels under hypoxic conditions as well as VEGF-induced DLL4 expression in ECs. "
2.	Hypoxia (Hypoxemia) 01/01/2023 - "Furthermore, steppogenin suppressed hypoxia-induced vascular EC proliferation and migration as well as VEGF-induced sprouting of EC spheroids. "
3.	Neuroinflammatory Diseases 12/02/2017 - "These results suggested that steppogenin (1) exerted antineuroinflammatory effects against acute neuroinflammation in BV2 and rat primary microglial cells by suppressing the activation of NF-κB and MAPK signaling and the production of proinflammatory mediators and cytokines."

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Cytokines
3.	Retinal Pigments (Pigments, Visual)
4.	Proteins (Proteins, Gene)