N-lactoyl-phenylalanine

01/01/2022 - "Conversely, genetic ablation of Lac-Phe biosynthesis in mice increases food intake and obesity following exercise training. "
01/01/2022 - "Outrunning obesity with Lac-Phe?"
01/01/2023 - "A better understanding of the regulation of CNDP2 expression in diverse tissues in mammals might be of high importance in the treatment of obesity, considering its role in the synthesis of Lac-Phe, a metabolite that decreases body weight and fat mass selectively in mice fed with a high-fat diet. "
12/22/2022 - "Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity."
11/04/2023 - "Lac-Phe mediates the anti-obesity effect of metformin."

01/01/2023 - "Further research is needed to find out how these two strategies lead to the upregulation of CNDP2 expression and whether this increased expression of CNDP2 might translate to reduced body weight and fat mass through higher Lac-Phe levels."
01/01/2023 - "A better understanding of the regulation of CNDP2 expression in diverse tissues in mammals might be of high importance in the treatment of obesity, considering its role in the synthesis of Lac-Phe, a metabolite that decreases body weight and fat mass selectively in mice fed with a high-fat diet. "
01/01/2022 - "Chronic administration of Lac-Phe decreases adiposity and body weight and improves glucose homeostasis. "
01/01/2023 - "We hypothesized that these t10-c12 CLA treatment- or caloric-restricted diet-mediated increases in CNDP2 expression might contribute to their anti-obesity effects, possibly due to increased Lac-Phe levels and ultimately due to Lac-Phe-mediated decreases in daily food consumption, reduced body weight and fat mass. "

12/22/2022 - "Quantification of Lac-Phe during an exercise test could be employed as a tool to predict and potentially improve the individual response to exercise-based lifestyle interventions in overweight humans and those with obesity."

12/22/2022 - "Lac-Phe produced during physical activity could contribute to weight loss by acting as a signaling molecule that regulates food intake, as previously shown in mice. "
12/22/2022 - "N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. "