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Outrunning obesity with Lac-Phe?

Abstract
Lactate released from skeletal muscle during high-intensity exercise gives rise to a surge in circulating lactate-derived pseudo-dipeptide metabolites including N-lactoyl-phenylalanine (Lac-Phe). In a recent Nature paper, Li et al. use genetic and pharmacological evidence to now propose Lac-Phe to be an "exercise hormone" that suppresses appetite and obesity.
AuthorsJens Lund, Christoffer Clemmensen, Thue W Schwartz
JournalCell metabolism (Cell Metab) Vol. 34 Issue 8 Pg. 1085-1087 (08 02 2022) ISSN: 1932-7420 [Electronic] United States
PMID35921816 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 Elsevier Inc. All rights reserved.
Chemical References
  • Lactic Acid
  • Phenylalanine
Topics
  • Exercise (physiology)
  • Humans
  • Lactic Acid
  • Muscle, Skeletal
  • Obesity
  • Phenylalanine

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