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cbr-5884

Also Known As:

ethyl 5-(furan-2-carbonylamino)-3-methyl-4-thiocyanatothiophene-2-carboxylate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - cbr-5884: 3
  - Furans: 85
    - cbr-5884: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - cbr-5884: 3

Experts

1.	Depner, Cornelia: 1 article (01/2020)
2.	Engel, Anna L: 1 article (01/2020)
3.	Klann, Kevin: 1 article (01/2020)
4.	Lorenz, Nadja I: 1 article (01/2020)
5.	Luger, Anna-Luisa: 1 article (01/2020)
6.	Münch, Christian: 1 article (01/2020)
7.	Ronellenfitsch, Michael W: 1 article (01/2020)
8.	Steinbach, Joachim P: 1 article (01/2020)
9.	Anglin, Justin L: 1 article (02/2016)
10.	Asara, John M: 1 article (02/2016)

Related Diseases

1.	Neoplasms (Cancer) 02/16/2016 - "CBR-5884 inhibited de novo serine synthesis in cancer cells and was selectively toxic to cancer cell lines with high serine biosynthetic activity. "
2.	Hypoxia (Hypoxemia) 01/01/2020 - "Pharmacological inhibition of PHGDH with CBR-5884 reduced proliferation and sensitised cells profoundly to hypoxia-induced cell death. "
3.	Ovarian Epithelial Carcinoma 01/01/2022 - "Results showed that CBR-5884 inhibited epithelial ovarian cancer cell proliferation, migration, and invasion and increases cell ROS level. " 01/01/2022 - "Thus, we investigated the function and possible mechanism of PHGDH inhibitor CBR-5884 on epithelial ovarian cancer in vitro and in vivo. " 01/01/2022 - "However, the role of PHGDH inhibitor CBR-5884 in cell ROS level and its downstream pathways has not been explored in epithelial ovarian cancer. " 01/01/2022 - "In conclusion, PHGDH inhibitor CBR-5884 inhibits epithelial ovarian cancer proliferation, migration, and invasion through activating ROS/Wnt/β-catenin pathway and plays a synergistic role with PARP inhibitor olaparib, which provided a theoretical basis for PHGDH inhibitor CBR-5884 in clinical treatment." 01/01/2022 - "PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib."

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