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DA-1241

GPR119 agonist

Also Known As:

3-(4-(3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)propoxy)-2,6-difluorophenyl)-5-isopropyl-1,2,4-oxadiazole

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Kang, Eun Seok: 1 article (01/2022)
2.	Kim, Ryeong-Hyeon: 1 article (01/2022)
3.	Kim, Youjin: 1 article (01/2022)
4.	Lee, Hangkyu: 1 article (01/2022)
5.	Lee, Si Woo: 1 article (01/2022)
6.	Park, Hyun Ki: 1 article (01/2022)
7.	Wang, Hyejin: 1 article (01/2022)
8.	Chae, Yuna: 1 article (12/2021)
9.	Cheong, Ye Hwang: 1 article (12/2021)
10.	Hong, Ki Whan: 1 article (12/2021)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2023 - "GPR119 activation by DA-1241 alleviates hepatic and systemic inflammation in MASH mice through inhibition of NFκB signaling." 10/01/2023 - "In DIO-MASH mice, DA-1241 significantly reduced biochemical parameters related to steatosis, inflammation and fibrosis in the liver with reduced plasma liver enzymes. " 10/01/2023 - "Notably, DA-1241 alone and in combination reduced liver inflammation and restored inflammation-related hepatic gene expression, leading to remission of systemic inflammation as assessed by plasma inflammatory cytokines and chemokines. "
2.	Fatty Liver 01/01/2022 - "DA-1241 reduced triglyceride content in the liver thereby improved fatty liver. "
3.	Insulinoma 01/01/2022 - "Insulinoma cell line (INS-1E) cells and mouse islets were used to find whether DA-1241 directly stimulate insulin secretion in beta cell. " 12/01/2021 - "In HIT-T15 insulinoma cells subjected to ER stress, decreased cell viability was significantly rescued by treatment with DA-1241. " 12/01/2021 - "DA-1241 increased intracellular cAMP in HIT-T15 insulinoma cells (EC50, 14.7 nM) and increased insulin secretion (EC50, 22.3 nM) in association with enhanced human insulin promoter activity. "
4.	Fibrosis (Cirrhosis) 10/01/2023 - "In DIO-MASH mice, DA-1241 significantly reduced biochemical parameters related to steatosis, inflammation and fibrosis in the liver with reduced plasma liver enzymes. "
5.	Body Weight (Weight, Body) 01/01/2022 - "Although DA-1241 treatment did not affect body weight gain and amount of food intake, fasting blood glucose level decreased along with increase in GLP-1 level. "

Related Drugs and Biologics

1.	Chemokines
2.	Cytokines
3.	Triglycerides (Triacylglycerol)
4.	Glucagon-Like Peptide 1 (GLP 1)
5.	Insulin (Novolin)
6.	Enzymes
7.	Blood Glucose (Blood Sugar)