mito-FF

self-assembly peptide that targets mitochondria, and consists of diphenylalanine, TPP, and pyrene

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2017 - "The Mito-FF fibrils induce mitochondrial dysfunction via membrane disruption to cause apoptosis. "
2.	Stomach Neoplasms (Stomach Cancer) 08/25/2020 - "The anticancer effects and mechanisms of 5-FU and Mito-FF, individually or in combination, were compared through both in vitro and in vivo models of gastric cancer. " 08/25/2020 - "We conclude that the combination of 5-FU and Mito-FF exerts potent antineoplastic activity against gastric cancer cells, primarily by promoting ROS generation and suppressing the activities of antioxidant enzymes." 08/25/2020 - "Interestingly, we found that combining 5-FU with Mito-FF leads to a significant increase of reactive oxygen species (ROS) and reduction of antioxidant enzymes in gastric cancer cells. " 08/25/2020 - "Here, we provide the possibility of a novel chemotherapeutic agent against gastric cancer cells, comprising the combination of 5-fluorouracil (5-FU) and a mitochondria-targeting self-assembly peptide, which is a phenylalanine dipeptide with triphenyl phosphonium (Mito-FF). "

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Phenylalanine (L-Phenylalanine)
3.	Peptides (Polypeptides)
4.	Fluorouracil (Carac)
5.	Enzymes
6.	Dipeptides
7.	Antioxidants
8.	Antineoplastic Agents (Antineoplastics)