alpha2 Subunit Collagen Type I

Also Known As:

Collagen Type I, alpha2 Subunit; COL1A2; Collagen Type 1 alpha-2; Collagen Type I, alpha2 Chain; Collagen alpha2(I); alpha 2 Collagen Type I; alpha 2(I) Collagen; alpha-2 Type 1 Collagen; alpha2 Type 1 Collagen; alpha2(I)-Collagen

Networked: 662 relevant articles (7 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Collagen: 52417
      - Fibrillar Collagens: 517
        Collagen Type I: 5821
        alpha2 Subunit Collagen Type I: 662
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Scleroproteins: 74
    - Extracellular Matrix Proteins: 3148
      - Collagen: 52417
        Fibrillar Collagens: 517
        Collagen Type I: 5821
        alpha2 Subunit Collagen Type I: 662

Experts

1.	Rauch, Frank: 13 articles (01/2022 - 03/2009)
2.	Glorieux, Francis H: 7 articles (01/2022 - 03/2009)
3.	Ren, Xiuzhi: 7 articles (03/2020 - 08/2015)
4.	Marini, Joan C: 7 articles (01/2020 - 01/2010)
5.	Byers, Peter H: 7 articles (08/2017 - 05/2004)
6.	Zhang, Hao: 6 articles (05/2021 - 07/2011)
7.	Bou-Gharios, George: 6 articles (09/2016 - 07/2005)
8.	Inagaki, Yutaka: 6 articles (09/2015 - 10/2003)
9.	Phillips, Charlotte L: 5 articles (01/2022 - 02/2010)
10.	Mäkitie, Outi: 5 articles (12/2020 - 05/2005)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2023 - "This study aims to verify the hypothesis that nitrated CREB promotes MI-induced myocardial fibrosis via regulating the transcription of Col1a2 and Cxcl12. " 08/15/2023 - "Hepatic CCN2 expression was significantly induced in NASH patients with F3-F4 fibrosis and was positively correlated with hepatic Col1A1, Col1A2, Col3A1, or αSMA expression. " 01/01/2023 - "Immunofluorescence staining revealed the activation of IL6-STAT3 and TGF-β-SMAD2/3 pathways in these cells, likely mediating the upregulation of COL1A1 and COL1A2 and excessive fibrosis in the lung tissues. " 01/01/2023 - "Four hub genes (ITGBL1, SPINT1, COL1A2, and THBS2) were ultimately identified, which may be associated with immune infiltration, fibrosis progression, and activity score. " 12/13/2022 - "Retraction Notice to: miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM."
2.	Osteogenesis Imperfecta (Lobstein Disease) 06/01/2021 - "This study investigated the characteristics of DI teeth associated with osteogenesis imperfecta (OI) and COL1A2 mutations. " 05/01/2021 - "This study describes the mutations in the main pathogenic genes, COL1A1 and COL1A2, and the clinical characteristics of osteogenesis imperfecta in China. " 03/01/2020 - "To increase the precision of the diagnosis of osteogenesis imperfecta (OI), we used HRM to explore COL1A1/COL1A2 mutations in 87 Chinese OI patients and to perform population-based studies of the relationships between their genotypes and phenotypes. " 07/10/2023 - "[Analysis of COL1A1 and COL1A2 gene variants in two fetuses with osteogenesis imperfecta]." 06/02/2023 - "The first objective of the present work was to further investigate the properties of tendons in the osteogenesis imperfecta mouse (oim), a model characterized by a mutation in the COL1A2 gene. "
3.	Neoplasms (Cancer) 07/20/2022 - "The relationship between COL1A1 and COL1A2 gene expression and clinicopathological features was analyzed by the Cancer Genome Atlas (TCGA) database, and the relationship between the expression levels of both and overall survival (OS) and disease-free progression survival (DFS) of MPM patients was dynamically analyzed by gene expression profiling, and the factors affecting the prognosis of MPM patients were explored by Cox proportional risk regression model. " 01/01/2018 - "Conclusions: Our study identified COL1A2 as a novel tumor suppressor in CRC and provided a potential therapeutic approach to treat CRC." 01/20/2024 - "Six common genes (COL11A1, COL12A1, COL1A1, COL1A2, COL5A1, and COL5A2) showed significantly increased in these three cancers, therebysupporting their oncogenic role. " 10/07/2023 - "The prognostic values of COL1A2 for 17 cancer types of interest were estimated from GEPIA database. " 10/07/2023 - "We performed the pan-cancer analysis of COL1A2 expression in 33 types of human cancers from TIMER database and integrated data combined TCGA with GTEx. "
4.	Stress Fractures (Stress Fracture) 01/01/2022 - "The present study describes a novel de novo heterozygous missense variant in COL1A2 gene, possibly inducing a propensity to trabecular microfractures. " 10/21/2010 - "Eight genes involved in bone metabolism or pathology (COL1A1, COL1A2, OPG, ESR1, VDR, CTR, LRP5, IL-6) were examined in 72 military conscripts with a femoral neck stress fracture and 120 controls. " 01/01/2012 - "Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. "
5.	Non-alcoholic Fatty Liver Disease 01/01/2023 - "In addition, ITGBL1, COL1A2, and THBS2 might be associated with transforming from nonalcoholic steatohepatitis (NASH) to HCC. " 01/01/2022 - "Besides, RHBDF1, COL3A1, QSOX1, STING1, COL5A1, IGFBP7, COL4A2, COL1A1, FKBP10 and COL1A2 also showed a strong power in the diagnosis of NAFLD. " 08/21/2021 - "Nine nodes including COL3A1, CXCL9, CYCS, CXCL10, THY1, COL1A2, SAA1, CDKN1A, and JUN in the dynamic networks were commonly identified in health- and obesity-derived NAFLD. " 01/01/2022 - "THY1, COL1A1, COL1A2, COL3A1 and RHBDF1 could be served as candidate biomarkers to evaluate the progression of NAFLD." 06/01/2017 - "In comparison, CD1d-deficient and CD8-T cell depleted mice fed HFHC had lower hepatic triglyceride content, lower ALT levels, as well reduced α-smooth muscle actin (αSMA), collagen type 1 alpha 1 (Col1a1), collagen type 1 alpha 2 (Col1a2) mRNA expression, lower activated resident macrophages and infiltrating macrophages and improved NAFLD activity scores. "

Related Drugs and Biologics

1.	Collagen Type I (Type I Collagen)
2.	Messenger RNA (mRNA)
3.	Collagen
4.	Interleukin-6 (Interleukin 6)
5.	Hydroxyproline (4 Hydroxyproline)
6.	Alkaline Phosphatase
7.	Keratin-19 (Keratin 19)
8.	Triglycerides (Triacylglycerol)
9.	Calcium Gluconate (CBG)
10.	Alanine Transaminase (SGPT)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Filtering Surgery
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Ventriculostomy