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fropofol

Also Known As:

2-Fluoro-1,3-diisopropyl-benzene

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Propofol: 7663
        fropofol: 2

Experts

1.	Bu, Weiming: 2 articles (01/2020 - 01/2018)
2.	Eckenhoff, Roderic: 2 articles (01/2020 - 01/2018)
3.	Gao, Wei Dong: 2 articles (01/2020 - 01/2018)
4.	Huang, Yiyuan: 2 articles (01/2020 - 01/2018)
5.	Liu, Wenjie: 2 articles (01/2020 - 01/2018)
6.	Lu, Haisong: 2 articles (01/2020 - 01/2018)
7.	Ren, Xianfeng: 2 articles (01/2020 - 01/2018)
8.	Abraham, Roselle: 1 article (01/2020)
9.	Dailey, William P: 1 article (01/2020)
10.	Gabrielson, Kathleen: 1 article (01/2020)

Related Diseases

1.	Heart Diseases (Heart Disease) 01/01/2018 - "From a clinical standpoint, these findings are particularly significant, given that fropofol is a nonanesthetic small molecule that decreases myocardial contractility specifically and thus may be useful in the treatment of hypercontractile cardiac disorders.-Ren, X., Schmidt, W., Huang, Y., Lu, H., Liu, W., Bu, W., Eckenhoff, R., Cammarato, A., Gao, W. "
2.	Hypertrophy 01/01/2020 - "In whole-animal studies, chronic intra-abdominal administration of fropofol prevented hypertrophy development and diastolic dysfunction. " 01/01/2020 - "Direct inhibition of myofilament contraction by fropofol prevents HCM disease phenotypic expression and progression, suggesting that increased myofilament contractile force is the primary trigger for hypertrophy development and HCM disease progression."
3.	Disease Progression 01/01/2020 - "Here, we tested whether the small molecule fropofol prevents HCM phenotype expression and disease progression by directly depressing myofilament force development. " 01/01/2020 - "Direct inhibition of myofilament contraction by fropofol prevents HCM disease phenotypic expression and progression, suggesting that increased myofilament contractile force is the primary trigger for hypertrophy development and HCM disease progression." 01/01/2020 - "Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy."
4.	Fibrosis (Cirrhosis) 01/01/2020 - "Chronic fropofol treatment also led to attenuation of prohypertrophic and profibrotic gene expression, reductions in cell size, and decreases in tissue fibrosis. "
5.	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/01/2020 - "Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy."