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QPX7728

ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases

Also Known As:

(1Ar,7bS)-5-fluoro-2-hydroxy-1a,7b-dihydro-1H-cyclopropa(c)(1,2)benzoxaborinine-4-carboxylic acid

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Acids: 53217
  - Noncarboxylic Acids
    - Borinic Acids
      - QPX7728: 3
- Boron Compounds: 91
  - Borinic Acids
    - QPX7728: 3
Organic Chemicals: 133
- Carboxylic Acids: 973
  - QPX7728: 3
- Boron Compounds: 91
  - Borinic Acids
    - QPX7728: 3

Experts

1.	Griffith, David C: 2 articles (12/2021 - 10/2020)
2.	Sabet, Mojgan: 2 articles (12/2021 - 10/2020)
3.	Tarazi, Ziad: 2 articles (12/2021 - 10/2020)
4.	Boyer, Serge H: 1 article (12/2021)
5.	Dudley, Michael N: 1 article (12/2021)
6.	Hecker, Scott J: 1 article (12/2021)
7.	Lomovskaya, Olga: 1 article (12/2021)
8.	Parkinson, Jonathan: 1 article (12/2021)
9.	Reddy, K Raja: 1 article (12/2021)
10.	González-Bello, Concepción: 1 article (01/2021)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2021 - "The efficacy of taniborbactam and QPX7728 is compared with the cyclic boronate inhibitor vaborbactam, which is the first boron-based β-lactamase inhibitor approved by the FDA in combination with meropenem for the treatment of complicated urinary tract infections."
2.	Infections 10/20/2020 - "The objective of these studies was to evaluate the activity of QPX7728 in combination with multiple beta-lactams against carbapenem-resistant Klebsiella pneumoniae isolates in a neutropenic mouse thigh infection model. "
3.	Gram-Negative Bacterial Infections 12/09/2021 - "In recognition of the need for effective oral therapies to treat Gram-negative bacterial infections, efforts were directed toward identifying an oral prodrug of β-lactamase inhibitor clinical candidate QPX7728. "
4.	Body Weight (Weight, Body) 10/20/2020 - "pneumoniae were tested with aztreonam, biapenem, cefepime, ceftazidime, ceftolozane, and meropenem alone or in combination with 12.5, 25, or 50 mg/kg of body weight of QPX7728 every 2 hours for 24 hours. "
5.	Bacterial Infections (Bacterial Infection) 10/20/2020 - "Overall, these data suggest that QPX7728 administered in combination with different partner beta-lactam antibiotics may have utility in the treatment of bacterial infections due to carbapenem-resistant K. "

Related Drugs and Biologics

1.	Meropenem (Merrem)
2.	Boron
3.	taniborbactam
4.	vaborbactam
5.	beta-Lactams
6.	Carbapenems (Carbapenem Antibiotics)
7.	Prodrugs
8.	Ceftazidime (Fortum)
9.	Aztreonam
10.	beta Lactam Antibiotics

Related Therapies and Procedures

1.	Therapeutics