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GV-971

a sodium oligomannate

Networked: 4 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - GV-971: 4
- Sugars: 11126
  - Monosaccharides: 889
    - Hexoses: 549
      - Mannose: 1927
        GV-971: 4

Experts

1.	Lin, Peng-Xing: 1 article (05/2022)
2.	Xue, Li-Hong: 1 article (05/2022)
3.	Zhang, Ling-Feng: 1 article (05/2022)
4.	Zhang, Yi-Pan: 1 article (05/2022)
5.	Chang, Shuaishuai: 1 article (10/2019)
6.	Chu, Xingkun: 1 article (10/2019)
7.	Ding, Jian: 1 article (10/2019)
8.	Du, Chen: 1 article (10/2019)
9.	Feng, Teng: 1 article (10/2019)
10.	Ge, Changrong: 1 article (10/2019)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 05/01/2022 - "GV-971 is as effective as donepezil in the treatment of Alzheimer's disease, and may even be better. " 01/01/2023 - "GV-971 (sodium oligomannate) is a China Food and Drug Administration (CFDA)-approved drug for treating Alzheimer's disease, and it could inhibit Aβ fibril formation in vitro and in mouse studies. "
2.	Dysbiosis 10/01/2019 - "Furthermore, GV-971, a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China, suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation, harnesses neuroinflammation and reverses the cognition impairment. "
3.	Neuroinflammatory Diseases 10/01/2019 - "Furthermore, GV-971, a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China, suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation, harnesses neuroinflammation and reverses the cognition impairment. "
4.	Synucleinopathies 08/10/2023 - "Future studies are needed to further assess GV-971 as a promising disease-modifying therapy for PD and other synucleinopathies." 08/10/2023 - "This study aimed to further evaluate the therapeutic effects of GV-971 on synucleinopathies using cellular and animal models and explore its associated molecular mechanisms. "
5.	Nausea 05/01/2022 - "There were 2 cases of adverse reaction of increased stool frequency in GV-971 (5.67%), and 2 cases of adverse reaction of nausea in donepezil group (8.33%), the difference was statistically significant. "

Related Drugs and Biologics

1.	Sodium
2.	Phenylalanine (L-Phenylalanine)
3.	Isoleucine (L-Isoleucine)
4.	Donepezil (Aricept)
5.	Therapeutic Uses

Related Therapies and Procedures

1.	Therapeutics