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WZ26

TrxR1 inhibitor

Also Known As:

curcuminoid WZ26

Networked: 3 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Diarylheptanoids: 471
        Curcumin: 10678
        WZ26: 3
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        Curcumin: 10678
        WZ26: 3
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        Diarylheptanoids: 471
        Curcumin: 10678
        WZ26: 3

Experts

1.	Xia, Yiqun: 2 articles (01/2019 - 01/2016)
2.	Zou, Peng: 2 articles (01/2019 - 01/2016)
3.	Shao, Rongrong: 1 article (01/2019)
4.	Shen, Huanpei: 1 article (01/2019)
5.	Shen, Xin: 1 article (01/2019)
6.	Wang, Bin: 1 article (01/2019)
7.	Zhang, Jingjing: 1 article (01/2019)
8.	Zhang, Tingting: 1 article (01/2019)
9.	Zheng, Peisen: 1 article (01/2019)
10.	Chen, Minxiao: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 12/31/2023 - "In this study, we evaluated the anti-tumor effect of WZ26 in both CCA cells and CCA xenograft mouse model. " 12/31/2023 - "Our results show that WZ26 significantly inhibited cell growth and induced mitochondrial apoptosis in CCA cell lines, leading to significant inhibition of tumor growth in xenograft tumor mouse model. " 12/31/2023 - "The underlying molecular anti-cancer mechanism of WZ26 was also studied. " 12/31/2023 - "However, the anti-tumor effect of WZ26 against CCA is unclear. " 01/01/2016 - "WZ26 also exhibited potent anti-tumor effects in human gastric cancer cell xenograft models. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2016 - "WZ26 could be considered as a potential chemotherapeutic agent for the treatment of advanced gastric cancer. " 01/01/2016 - "WZ26 also exhibited potent anti-tumor effects in human gastric cancer cell xenograft models. " 01/01/2016 - "In vitro, WZ26 showed higher chemical stability and much stronger anti-proliferative effects than curcumin, accompanied by dose-dependent induction of cell cycle arrest and apoptosis in gastric cancer cells. " 01/01/2016 - "The present study aims to identify the anti-cancer effects and mechanisms of WZ26, an analog of curcumin, in gastric cancer cells. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "In the present study, we further explored the mechanism and target of WZ26 in colon cancer cells. " 01/01/2019 - "Furthermore, we found that WZ26 significantly enhances cisplatin-induced cell growth inhibition in colon cancer cells. " 01/01/2019 - "Curcuminoid WZ26, a TrxR1 inhibitor, effectively inhibits colon cancer cell growth and enhances cisplatin-induced cell death through the induction of ROS." 01/01/2019 - "This study discloses a previously unrecognized mechanism underlying the biological activity of WZ26, and reveals that WZ26 and cisplatin combinational treatment might potentially become a more effective regimen in colon cancer therapy." 01/01/2019 - "In vivo, WZ26 combined with cisplatin significantly inhibits tumor growth in a colon cancer xenograft model. "
4.	Cholangiocarcinoma 12/31/2023 - "Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma."
5.	Body Weight (Weight, Body) 01/01/2019 - "Remarkably, WZ26 attenuates the body weight loss evoked by cisplatin treatment. "

Related Drugs and Biologics

1.	Curcumin
2.	Cisplatin (Platino)
3.	Thioredoxin Reductase 1
4.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Therapeutics