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GRN-41

generated from alternative splicing of the Mozambique tilapia PGRN1 gene

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        GRN-41: 1
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - GRN-41: 1
  - Antimicrobial Cationic Peptides: 414
    - GRN-41: 1

Experts

1.	Gong, Hong-Yi: 1 article (04/2018)
2.	Lin, Hong-Jie: 1 article (04/2018)
3.	Lin, Wen-Fu: 1 article (04/2018)
4.	Wu, Jen-Leih: 1 article (04/2018)
5.	Wu, Sheng-Han: 1 article (04/2018)

Related Diseases

1.

04/01/2018 - "The expression of GRN-41 and PGRN1 were further induced in the spleen of tilapia challenged with Vibrio vulnificus at 3 h post infection (hpi) and 6 hpi, respectively. "
04/01/2018 - "It indicates tilapia GRN-41 is a potent peptide against V. vulnificus infection. "
04/01/2018 - "The secreted tilapia GRN-41 can induce the expression of innate immune response-related genes, such as TNFa, TNFb, IL-8, IL-1β, IL-6, IL-26, IL-21, IL-10, complement C3, lysozyme (Lyz) and the hepatic antimicrobial peptide hepcidin (HAMP), in adult transgenic zebrafish without V. vulnificus infection. "

Related Drugs and Biologics

1.	Hepcidins
2.	Interleukin-10 (Interleukin 10)
3.	Interleukin-8 (Interleukin 8)
4.	Interleukin-6 (Interleukin 6)
5.	Peptides (Polypeptides)
6.	Muramidase (Lysozyme)
7.	Complement C3 (C3 Complement)
8.	Antimicrobial Peptides
9.	interleukin-21 (interleukin 21)