ARC 118925XX

a competitive P2Y2 receptor antagonist

Also Known As:

5-((5-(6,13-dimethyl-2-tricyclo(9.4.0.03,8)pentadeca-1(11),3(8),4,6,9,12,14-heptaenyl)-2-oxo-4-sulfanylidenepyrimidin-1-yl)methyl)-N-(2H-tetrazol-5-yl)furan-2-carboxamide; AR-C118925XX; ARC118925XX

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Cuthbertson, P: 1 article (10/2021)
2.	Mansfield, K J: 1 article (10/2021)
3.	McEwan, T B-D: 1 article (10/2021)
4.	Sanderson-Smith, M L: 1 article (10/2021)
5.	Sluyter, R: 1 article (10/2021)
6.	Sophocleous, R A: 1 article (10/2021)
7.	Chang, Li-Yun: 1 article (12/2019)
8.	Cheng, Ka-Shun: 1 article (12/2019)
9.	Leung, Yuk-Man: 1 article (12/2019)
10.	Shiao, Lian-Ru: 1 article (12/2019)

Related Diseases

1.	Wounds and Injuries (Trauma) 10/15/2021 - "AR-C118925XX decreased wound closure in a concentration-dependent fashion. " 10/15/2021 - "The non-selective P2Y receptor antagonist suramin and the selective P2Y2 receptor antagonist AR-C118925XX, but not other P2 antagonists, decreased wound closure. "
2.	Neoplasms (Cancer) 01/01/2023 - "In vivo experiments showed that ATP-induced tumor growth, while AR-C118925XX inhibited ATP-induced tumor growth. "
3.	Fibrosis (Cirrhosis) 01/01/2019 - "The amount of ATP in bleomycin-treated skin was increased, and administration of AR-C118925XX significantly inhibited bleomycin-induced dermal fibrosis in mice. "
4.	AIDS-Related Complex (ARC) 12/01/2019 - "In a previous publication when we studied the purinergic receptor with which ATP interacted in mouse brain bEND.3 endothelial cells, we observed addition of 3 μm ARC 118925XX (ARC; selective P2Y2 antagonist) strongly suppressed ATP-triggered Ca2+ release, suggesting the response was mediated via P2Y2 receptors. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Purinergic P2Y2 Receptors
3.	Suramin (Suramin Sodium)
4.	Purinergic Receptors (Receptors, Purine)
5.	Bleomycin (Blenoxane)
6.	indium-bleomycin