HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

KMRC011

toll-like receptor 5 (TLR5) agonist, structure unknown, flagellin derived

Also Known As:

KMRC-011

Networked: 4 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Fragments: 373
    - KMRC011: 4

Experts

1.	Choi, Chi-Min: 1 article (11/2021)
2.	Choi, Hyejung: 1 article (11/2021)
3.	Kim, Jungryul: 1 article (11/2021)
4.	Ko, Jae-Wook: 1 article (11/2021)
5.	Lee, Woo-Jong: 1 article (11/2021)
6.	Noh, Young-Woock: 1 article (11/2021)
7.	Park, Jin-Sol: 1 article (11/2021)
8.	Yang, Eunsol: 1 article (11/2021)

Related Diseases

1.	Acute Radiation Syndrome 11/01/2021 - "A first-in-human study of KMRC011, a potential treatment for acute radiation syndrome, to explore tolerability, pharmacokinetics, and pharmacodynamics." 11/01/2021 - "KMRC011 is a novel Toll-like receptor 5 agonist under development as a treatment for acute radiation syndrome (ARS). " 01/01/2023 - "10 of these studies had been completed, 3 with promising results: KMRC011 increased G-CSF, IL-6, and neutrophil counts suggesting potential for the treatment of hematopoietic acute radiation syndrome (H-ARS); GC4419 reduced the number of patients with severe oral mucositis and its duration; the combination of enoxaparin, pentoxifylline, and ursodeoxycholic acid reduced the incidence of focal radiation-induced liver injury. "
2.	Stomatitis 01/01/2022 - "This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. " 01/01/2022 - "The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. " 01/01/2023 - "10 of these studies had been completed, 3 with promising results: KMRC011 increased G-CSF, IL-6, and neutrophil counts suggesting potential for the treatment of hematopoietic acute radiation syndrome (H-ARS); GC4419 reduced the number of patients with severe oral mucositis and its duration; the combination of enoxaparin, pentoxifylline, and ursodeoxycholic acid reduced the incidence of focal radiation-induced liver injury. "
3.	Colitis 01/28/2023 - "Overall, KMRC011 showed protective effects against murine colitis by inhibiting NF-κB signaling." 01/28/2023 - "Protective Role of the Toll-Like Receptor 5 Agonist KMRC011 against Murine Colitis Induced by Citrobacter rodentium and Dextran Sulfate Sodium."
4.	Mucositis 01/01/2022 - "Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. "
5.	Ulcer 01/01/2022 - "Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. "

Related Drugs and Biologics

1.	Enoxaparin (Lovenox)
2.	Granulocyte Colony-Stimulating Factor (G-CSF)
3.	Interleukin-6 (Interleukin 6)
4.	Ursodeoxycholic Acid (Urso)
5.	Pentoxifylline (Trental)
6.	avasopasem manganese
7.	Toll-Like Receptors (Toll-Like Receptor)
8.	Dextran Sulfate
9.	Toll-Like Receptor 5