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BKI 1369

targets calcium-dependent protein kinase 1

Also Known As:

3-(2-Ethoxyquinolin-6-yl)-1-((1-methylpiperidin-4-yl)methyl)pyrazolo(3,4-d)pyrimidin-4-amine; BKI1369; Bumped Kinase Inhibitor 1369

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - BKI 1369: 4
  - Piperidines: 17
    - BKI 1369: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - BKI 1369: 4

Experts

1.	Joachim, Anja: 3 articles (01/2021 - 01/2019)
2.	Ruttkowski, Bärbel: 3 articles (01/2021 - 01/2019)
3.	Choi, Ryan: 3 articles (12/2020 - 01/2018)
4.	Hulverson, Matthew A: 3 articles (12/2020 - 01/2018)
5.	Ojo, Kayode K: 3 articles (12/2020 - 01/2018)
6.	Van Voorhis, Wesley C: 3 articles (12/2020 - 01/2018)
7.	Whitman, Grant R: 3 articles (12/2020 - 01/2018)
8.	Michaels, Samantha A: 2 articles (12/2020 - 01/2019)
9.	Shrestha, Aruna: 2 articles (12/2020 - 01/2019)
10.	Greber, Patricia: 1 article (12/2020)

Related Diseases

1.	Diarrhea 01/01/2018 - "Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis." 12/01/2020 - "Moreover, a significant increase in body weight gain and reduced number of diarrhea days were observed in BKI 1369 treated piglets compared to the control piglets, irrespective of time points and frequencies of treatment. " 01/01/2018 - "We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute diarrhea caused by Cryptosporidium hominis, the species responsible for most human cases. " 01/01/2019 - "Five-day treatment with BKI 1369 (10 mg/kg BW twice a day) effectively suppressed oocyst excretion and diarrhea and improved body weight gains in treated piglets without obvious side effects for both toltrazuril-sensitive, Wien-I and resistant, Holland-I C. "
2.	Body Weight (Weight, Body) 12/01/2020 - "suis 2 and 4 dpi with 20 mg BKI 1369/kg body weight completely suppressed oocyst excretion. " 12/01/2020 - "Moreover, a significant increase in body weight gain and reduced number of diarrhea days were observed in BKI 1369 treated piglets compared to the control piglets, irrespective of time points and frequencies of treatment. " 01/01/2019 - "Five-day treatment with BKI 1369 (10 mg/kg BW twice a day) effectively suppressed oocyst excretion and diarrhea and improved body weight gains in treated piglets without obvious side effects for both toltrazuril-sensitive, Wien-I and resistant, Holland-I C. "
3.	Infections 01/01/2021 - "Dose- and duration-dependent efficacy was seen when developing stages were treated with BKI 1369 after infection (days 0-1, 2-3 and 2-5) but not when sporozoites were pre-incubated with BKI 1369 before infection. " 12/01/2020 - "Pre-incubation of sporozoites with BKI 1369 completely failed to inhibit the infection in vitro unless treatment was prolonged post-infection. " 01/01/2019 - "In this comprehensive study, the efficacy, safety and pharmacokinetics of BKI 1369 in piglets experimentally infected with Cystoisospora suis (toltrazuril-sensitive, Wien-I and toltrazuril-resistant, Holland-I strains) were determined in vivo and in vitro using an established animal infection model and cell culture, respectively. "

Related Drugs and Biologics

1.	toltrazuril
2.	Phosphotransferases (Kinase)