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PZ-II-029

alpha 6 GABA A R-selective positive allosteric modulator

Also Known As:

7-methoxy-2-(4-methoxyphenyl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one; pyrazoloquinolinone compound 6

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Pyrazolones: 41
        PZ-II-029: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        PZ-II-029: 2

Experts

1.	Chang, Man-Hsin: 1 article (06/2022)
2.	Chiou, Lih-Chu: 1 article (06/2022)
3.	Cook, James: 1 article (06/2022)
4.	Knutson, Daniel E: 1 article (06/2022)
5.	Kubota, Hisayoshi: 1 article (06/2022)
6.	Lee, Hsin-Jung: 1 article (06/2022)
7.	Lee, Ming Tatt: 1 article (06/2022)
8.	Mihovilovic, Marko: 1 article (06/2022)
9.	Mouri, Akihiro: 1 article (06/2022)
10.	Nabeshima, Toshitaka: 1 article (06/2022)

Related Diseases

1.	Tremor (Tremors) 01/01/2023 - "Importantly, intra-cerebellar micro-injection of furosemide (an α6GABAAR antagonist) had a trend of blocking the effect of pyrazoloquinolinone Compound 6 or ethanol on harmaline-induced tremor. "
2.	Schizophrenia (Dementia Praecox) 06/01/2022 - "We have previously demonstrated that pyrazoloquinolinone Compound 6, an α6GABAAR-highly selective positive allosteric modulator (PAM), can rescue the disrupted prepulse inhibition (PPI) induced by methamphetamine (METH), an animal model mimicking the sensorimotor gating deficit based on the hyper-dopaminergic hypothesis of schizophrenia. "

Related Drugs and Biologics

1.	Methamphetamine (Desoxyn)
2.	Harmaline
3.	Furosemide (Lasix)
4.	Ethanol (Ethyl Alcohol)